FULL TEXT - https://www.drjjamesfrost.com/post/intrinsic-cellular-computation-far-reaching-implications-for-solving-the-cancer-problem

In my article Cancer’s Intelligence I conjectured that cancer is able to compute survival solutions to future environmental changes that it has not yet encountered. That is, that cancer can predict the future and ready itself to adapt to new, yet unseen environmental conditions, whether a change in oxygen tension or a chemotherapeutic drug.

A recent, exceedingly relevant paper entitled Trade-offs between cost and information in cellular prediction by Tjalma et al analyzes cellular adaptation and lays out the conditions for prediction of a survival response to an adverse environmental change. The cellular response is an intrinsically computed solution to future external events using the cell’s internal computational machinery. Historically, it has been thought that only higher organisms “can predict the future environment and initiate a response ahead of time”, but this is not the case.

At bottom, energy and time are two key computational limits. Energy (free energy) for computation, storing information, and the protein synthesis needed for future actions limits computation of the optimal solution for future survival moves.  Time is a factor in computing solutions and a in sensing and sampling the current and past environments sufficiently finely for accurate predictions. Optimal time averaging for the cell is key, which also has the advantage of filtering noise.

The Tjalma article elucidates the informational bounds a cell can possibly have about the future. The costs of a bit of informational sampling and processing are computed and compared.  As information-processing humans, we extract only the most useful information from the past environment as we plan future actions – the cell does the same. How and under what conditions a cell approaches the information bound for its internal computation is examined in detail by exploring Markovian and non-Markovian models and by examining the necessary fineness of temporal sampling of the environment and the cell’s computational speed. The information bottleneck theory is key in this analysis, as it dictates information compression for storage and its costs.

The article is a challenging, yet rewarding read and one that is intimately related to the vast computation ability of the cancer cell and more importantly, cancer cell networks. In a way, this article is the missing link between cancer’s computation from instantaneous, present environmental conditions – the constrained regime held by most cancer biologists – to the tracking and selective sampling of the past and the present to the response to yet-unseen future events – just as human and higher animal computation occurs.

For more information on the molecular imaging aspects of cancer characterization, treatment, and monitoring, please visit BioMolecular Imaging, LLC http://biomolecularimaging.com

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Intrinsic Cellular Computation: Far Reaching Implications for Solving the Cancer Problem

Dans cette capsule radiophonique captivante, vous découvrirez comment l'intelligence genrée influence la recherche et le développement ! Explorez avec moi comment les distinctions de genre dans la consommation impactent les décisions d'achat et comment les entreprises peuvent s'adapter pour répondre aux besoins évolutifs du marché. Plongez dans l'histoire inspirante de Nissan Motor Cie, illustrant comment l'intégration de l'intelligence genrée a transformé l'entreprise et conduit à une croissance remarquable. Ne manquez pas cette opportunité d'apprendre et d'inspirer le changement dans votre organisation !

Source photo: Amazingfotommm et Adobestock

Comment l'intelligence genrée influence-t-elle la recherche et le développement?

Dive into the stirring strains of "Change is Inevitable, Resistance is Futile," a powerful anthem for the modern age crafted by the visionary sounds of easycore rock emo. As we stand at the crossroads of history, this song beckons us to embrace the relentless tide of technological advancement.

Through the emotive resonance of acoustic guitar and poignant lyrics, the track explores the transformative journey from ancient tools to the digital era, urging us to not only accept but champion the innovations that propel us forward. Each chord and verse encapsulates the spirit of adaptation—the same spirit that turned wheels into cars and abacus beads into digital data.

"Change is Inevitable, Resistance is Futile" is more than just music; it's a call to action. It challenges listeners to break free from the shackles of fear and skepticism that often accompany the unknown and step boldly into a future where technology uplifts and expands human potential.

Join us in this melodious voyage that not only reflects on our past triumphs over change but also inspires a future where embracing innovation is key to humanity's progress. Let the music resonate, let the ideas permeate, and let us all move forward together. This is not just a song—it's a manifesto for progress.

Verse 1:
In a world where the abacus reigned,
Came the calculator, minds were trained.
From slide to digit, fears inflamed,
But look around, the world’s unchained.

Chorus:
Every new tool that shakes the frame,
Is just a step in the game.
From horse to car, from flame to forge,
We ride the wave of progress’ surge.

Verse 2:
Spreadsheets grew from paper sheets,
Complex data at our feets.
Cubed dimensions, unseen feats,
Yet in the end, innovation greets.

Bridge:
Imagine if the wheel was feared,
No industries far and near.
Fire’s warmth once deemed severe,
Now metals shine from sphere to sphere.

Verse 3:
The Industrial roar, a mighty sound,
New jobs blossomed all around.
What’s lost is found, what’s bound unbound,
In every tech, new hopes are crowned.

Chorus:
Every new tool that shakes the frame,
Is just a step in the game.
From horse to car, from flame to forge,
We ride the wave of progress’ surge.

Change Is Inevitable, Resistance Is Futile

Explorez le monde intérieur de votre préadolescent avec notre chronique radiophonique sur le développement moral et spirituel des préados. Découvrez comment passer de la 'morale de contrainte' à la 'morale de coopération' tout en favorisant leur épanouissement grâce à des conseils pratiques et des activités engageantes. Rejoignez-nous pour un voyage fascinant vers la découverte de soi et du monde qui nous entoure.

Source image: Papilouz_studio et Freepik

Conseils essentiels et pratiques pour les papas de préados, partie 6

We're tackling some of the most common challenges and misconceptions in fitness and nutrition. We'll explore the concept of eating more to reach your strength goals and the benefits of reverse dieting, including personal insights on these strategies. We'll discuss the importance of food quality, why many people quit within the first four weeks, and how to achieve sustainable progress. You'll learn about setting realistic goals, working with your body, and the critical role of sleep, mood, and digestion. We'll also debunk myths around cardio vs. strength training, highlight the importance of protein, and discuss metabolic adaptation. Whether you're frustrated with your current progress or looking for actionable tips, this episode offers valuable guidance for making meaningful changes. Let's dive in!
Hosted by Leanne Vogel.

Body Recomp Coach, Sarah Granetz: https://www.strong-by-sarah.com
  
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Change Your Body: Protein and Reverse Dieting with Sarah Granetz

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Learn Deeply & Continuously,

Patrick

Unlock Your Potential: The Power of 'Ambitiously Possible' Thinking

This week's episode explores the journey of Heartstopper from its origins as a webcomic to its successful adaptation into a TV series with Author Alice Oseman and Executive Producer Patrick Walters.

 The creators discuss the importance of staying true to the source material, the emotional resonance of the story, and the collaborative process that brings the characters to life. They emphasize the themes of hope and optimism that permeate the narrative, making it relatable and beloved by audiences worldwide.



Ready to learn more?
https://aliceoseman.com/heartstopper/



Join Tricia in the free AAIE Future Foresight Community:
https://app.glueup.com/event/aaie-leadership-learning-series-co-creating-future-foresight-skills-122479/

192: What's At The Heart Of Heartstopper?

Discover how Trump's tariffs could impact dropshipping and Shopify store owners, strategies for adaptation, and the long-term outlook for e-commerce businesses facing global trade shifts.

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Rwanda's Green Villages: Addressing climate change, poverty, & resettlement challenges through infrastructure & sustainable development.

Rwanda's Green Villages Amazing Climate Success?

Ugandan women are revolutionizing the coffee sector by overcoming gender and climate challenges, with companies like Kwezi Coffee and Zukuka Bora empowering female farmers through sustainable initiatives and economic growth in Uganda.

Ugandan Women Lead Inspiring Coffee Business

Join us on The Traffic Tribe-SEO], where we dive into the world of SEO, digital marketing, and website traffic. Hosted by Theotis and Olivia, seasoned SEO experts, each episode explores cutting-edge strategies, practical tips, and industry insights to help boost your online presence and drive organic growth. Whether you’re a business owner, marketer, or digital enthusiast, tune in to learn from top industry leaders and elevate your web traffic game. Perfect for anyone looking to demystify SEO and optimize their digital strategy for success.

Join Functional Medicine Practitioner and Holistic Nutritionist, Leanne Vogel as we seek answers on the fringes of the health space. Together we'll explore the principles of functional health to help you thrive in mind, body, and spirit. In each episode, we'll delve into the latest research, practical tips, and insightful interviews with experts in the field of functional medicine and holistic health. Join me on Tuesdays as we work to shift your perspective, and up-level your approach to a healthful life... because your health is worth pursuing.

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email: xyloquint@xyloquint.com

Reimagining K12 education to foster allyship and belonging one conversation at a time. Learn more at triciafriedman.com

"Wisdom isn't wisdom until it's shared." - Patrick Mosher

Molecular imaging Specialist
Clinical trials reader
Clinical radiology and nuclear medicine
Consulting for pharma, CROs, diagnostics, and biotech
Strategic partnering across industry, academia and government
Early stage companies and investment

New tracks tagged #Adaptation,