opium (also known as poppy tears, or Lachryma papaveris) is the dried latex obtained from the seed capsules of the opium poppy Papaver somniferum. Approximately 12 percent of opium is made up of the analgesic alkaloid morphine, which is processed chemically to produce heroin and other synthetic opioids for medicinal use and for the illegal drug trade. Opium's main psychoactive alkaloids, primarily morphine, act on μ-opioid receptors, causing analgesia and addiction with long-term use leading to tolerance, dependence, and increased cancer risk. The latex also contains the closely related opiates codeine and thebaine, and non-analgesic alkaloids such as papaverine and noscapine. The traditional, labor-intensive method of obtaining the latex is to scratch ("score") the immature seed pods (fruits) by hand; the latex leaks out and dries to a sticky yellowish residue that is later scraped off and dehydrated.

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Avoidant personality disorder (AVPD) is a mental health condition characterized by profound feelings of inadequacy, hypersensitivity to criticism or rejection, and avoidance of social situations due to a deep fear of being criticized, humiliated, or rejected. People with AVPD desire social connection but their maladaptive avoidance patterns, stemming from their feelings of being socially inept or inferior, lead to significant distress and difficulty functioning in daily life.

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