Cancer therapy has come a long way from its one-size-fits-all beginning to the awakening era of personalized medicine. This change has been largely driven by the discovery of biomarkers. Biomarkers can help refine patient selection for specific therapies. A blend of causal and correlative approaches is needed to elucidate the full potential of biomarkers in cancer research. This fusion of methodologies allows for a comprehensive exploration of biomarker efficacy, leading to more accurate predictions of drug response.

In a new paper, researchers Alberto Moscona-Nissan, Karl J. Habashy, Victor A. Arrieta, Adam M. Sonabend, and Crismita Dmello from the Universidad Panamericana School of Medicine, Northwestern University and Universidad Nacional Autónoma de México discuss causal and correlative approaches to identify potential biomarkers for predicting response to paclitaxel — a commonly used chemotherapeutic agent. On February 8, 2024, their research perspective was published in Oncotarget’s Volume 15, entitled, “Combining causal and correlative approaches to discover biomarkers of response to paclitaxel.”

“[…] studying the combination of non-overlapping biomarkers’ expression, in addition to clinical and sociodemographic data could generate predictive models for paclitaxel susceptibility.”

Full blog - https://www.oncotarget.org/2024/03/28/identifying-biomarkers-for-predicting-paclitaxel-response/

Paper DOI - https://doi.org/10.18632/oncotarget.28549

Correspondence to - Crismita Dmello - crismita.dmello@northwestern.edu, and Adam M. Sonabend - adam.sonabend@northwestern.edu

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Keywords - cancer, glioblastoma, predictive biomarker, CRISPR screen, paclitaxel

About Oncotarget 

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science).

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Identifying Biomarkers for Predicting Paclitaxel Response

Clinical Professor Muneer Ahmad explains why students are indispensable to the work of the Law School’s clinics. He discusses the Worker and Immigrant Rights Advocacy Clinic, including the extraordinary 24-hour period in which the clinic won a nationwide injunction against the Trump administration’s Muslim travel ban.

Season Two, Episode Eight: Muneer Ahmad

The Rev’d Dr. Jamie Hawkey, Canon Theologian of Westminster Abbey, joins us to talk about dialogues between the Anglican Communion and the Roman Catholic Church. We discuss church unity, prayer in theology, and engaging the public through mysticism and the arts. Jamie, Brandon, and Hannah get a chance to talk about their shared love of Italy.

15: Ecumenical Dialogues with Jamie Hawkey

BUFFALO, NY- April 29, 2024 – Oncotarget is a contributing #sponsor at the 19th International p53 Workshop, organized by the International Center for Genetic Engineering and Biotechnology (ICGEB), which takes place from May 13–16, 2024, in Trieste, Italy.

“Groundbreaking research and cutting-edge advancements in the field of the most studied human gene and most frequently mutated gene in cancer, will take center stage at the 19th International p53 Workshop.” – ICGEB.org

Among the 24 invited speakers at the 19th International p53 Workshop, 18 speakers have published new research on p53 in Oncotarget. These distinguished speakers who have published with Oncotarget include Dr. Andrei Gudkov — one of Oncotarget’s founding Editors-in-Chief. Dr. Gudkov will be speaking in the session on “p53 Inflammation and Immunity” and moderating the session on “Targeting p53 in Human Disease.”

“The event will gather leading scientists, clinicians, and researchers from around the world providing a unique opportunity to delve into the latest discoveries and innovations related to TP53 biology and explore the intricate role of TP53 in cancer and its potential for transformative impact in oncology.” – ICGEB.org

About Oncotarget 

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science).

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Joy Marie Clarkson, PhD joins us to discuss her latest book You Are a Tree: And Other Metaphors to Nourish Life, Thought, and Prayer. Hannah, Brandon, and Joy talk about what metaphors are and why they’re so useful in preaching, theology, and life. They ponder how humans are more like trees than machines and explore the metaphor of love as disease. Clarkson tells the story of how she ended up with her social media presence, and she shares a bit about her other books The Clubhouse and Aggressively Happy.

16: Metaphors with Joy Clarkson

The 104th Archbishop of Canterbury Rowan Williams joins Brandon and Hannah to talk about church unity in the face of difference, vocation, and prayer. He explains how to engage in contemplative prayer and offers hope for the future of the church.

17: The Church and Prayer with Rowan Williams

Academic Dean of Westcott House Karen O’Donnell joins us from Cambridge for an intro to feminist theology. Dr. O’Donnell describes what feminist theology and trauma theology are, talks about her own journey into these fields, and considers where we go from here. Brandon, Hannah, and Karen (of course) also talk prayer and hope.

18: Feminist Theology with Karen O’Donnell

Father Lizzie and Mother Laura join us to talk about their vocation stories, how they each ended up doing digital ministry (accidentally), and why they joined forces to create their new podcast, “And Also With You.”

19: Digital Ministry with Lizzie McManus-Dail and Laura Di Panfilo

Jonathan Wilson-Hartgrove joins us from the Yale Center for Public Theology and Public Policy. He describes the making of white, Christian nationalism and helps us see a different path forward, following the teachings of Jesus. He walks us through the reality of the New Right in the 1970s as a way for us to understand our positionality headed into the 2024 election.

21: Christianity in American Politics

Dr. Nadia Kizenko joins Ariana Hones (MDiv '25) in conversation to discuss Kizenko's research on Orthodox liturgy in Ukraine. The conversation is twofold. First, Kizenko explores the liturgical practices of the Ukrainian Orthodox Church and the Orthodox Church of Ukraine. She discusses how these two competing churches, both which can claim canonical status, respond liturgically in times of crisis. Second, Kizenko speaks about her most recent project creating a vesper service and how liturgy functions as a means to include or exclude different identities. Throughout the conversation, Kizenko makes the case for paying close attention to liturgy and the ways in which Orthodox tradition across time provides elements of subversion for its participants.

Orthodox Liturgy as Refuge and Resistance

BUFFALO, NY- April 30, 2024 – A new #researchpaper was #published on the #cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 8, entitled, “Senescent characteristics of human corneal endothelial cells upon ultraviolet-A exposure.”

In this new study, researchers Kohsaku Numa, Sandip Kumar Patel, Zhixin A. Zhang, Jordan B. Burton, Akifumi Matsumoto, Jun-Wei B. Hughes, Chie Sotozono, Birgit Schilling, Pierre-Yves Desprez, Judith Campisi (1948-2024), and Koji Kitazawa from Buck Institute for Research on Aging, Kyoto Prefectural University of Medicine, University of Cambridge, and California Pacific Medical Center investigated the senescent phenotypes of human corneal endothelial cells (hCEnCs) upon treatment with ultraviolet (UV)-A.

“We assessed cell morphology, senescence-associated β-galactosidase (SA-β-gal) activity, cell proliferation and expression of senescence markers (p16 and p21) in hCEnCs exposed to UV-A radiation, and senescent hCEnCs induced by ionizing radiation (IR) were used as positive controls.”

The researchers performed RNA sequencing and proteomics analyses to compare gene and protein expression profiles between UV-A- and IR-induced senescent hCEnCs — they also compared the results to non-senescent hCEnCs. Cells exposed to 5 J/cm2 of UV-A or to IR exhibited typical senescent phenotypes, including enlargement, increased SA-β-gal activity, decreased cell proliferation and elevated expression of p16 and p21. RNA-Seq analysis revealed that 83.9% of the genes significantly upregulated and 82.6% of the genes significantly downregulated in UV-A-induced senescent hCEnCs overlapped with the genes regulated in IR-induced senescent hCEnCs. Proteomics also revealed that 93.8% of the proteins significantly upregulated in UV-A-induced senescent hCEnCs overlapped with those induced by IR. In proteomics analyses, senescent hCEnCs induced by UV-A exhibited elevated expression levels of several factors part of the senescence-associated secretory phenotype.

“In this study, where senescence was induced by UV-A, a more physiological stress for hCEnCs compared to IR, we determined that UV-A modulated the expression of many genes and proteins typically altered upon IR treatment, a more conventional method of senescence induction, even though UV-A also modulated specific pathways unrelated to IR.”

DOI - https://doi.org/10.18632/aging.205761

Corresponding author - Koji Kitazawa - kkitazaw@koto.kpu-m.ac.jp

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About Aging-US

Aging publishes research papers in all fields of aging research including but not limited, aging from yeast to mammals, cellular senescence, age-related diseases such as cancer and Alzheimer’s diseases and their prevention and treatment, anti-aging strategies and drug development and especially the role of signal transduction pathways such as mTOR in aging and potential approaches to modulate these signaling pathways to extend lifespan. The journal aims to promote treatment of age-related diseases by slowing down aging, validation of anti-aging drugs by treating age-related diseases, prevention of cancer by inhibiting aging. Cancer and COVID-19 are age-related diseases.

Please visit our website at https://www.Aging-US.com​​ and connect with us:

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Cover Paper: Senescent Characteristics of Human Corneal Endothelial Cells Upon UV-A Exposure

Oncotarget is a primarily oncology-focused, peer-reviewed, open access journal. Papers are published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Oncotarget is now indexed by MEDLINE, PubMed and PMC/PubMed.

Read about the Oncotarget Scientific Integrity Process: https://www.oncotarget.com/scientific_integrity/

Identifying Biomarkers for Predicting Paclitaxel Response

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