BUFFALO, NY- November 1, 2023 – A new research paper was published in Oncotarget's Volume 14 on October 31, 2023, entitled, “FAAH inhibition ameliorates breast cancer in a murine model.”

Breast cancer is the leading cancer among females worldwide. Disease outcome depends on the hormonal status of the cancer and whether or not it is metastatic, but there is a need for more efficacious therapeutic strategies where first line treatment fails. In this new study, researchers Mallika Tripathy, Amy Bui, Jared Henderson, Jeffrey Sun, Christian Rutan Woods, Soumya Somani, Thao Doan, Anto Sam Crosslee Louis Sam Titus, and Chandra Mohan from the University of Houston’s Department Biomedical Engineering examined Fatty Acid Amide Hydrolase (FAAH) inhibition and endocannabinoids as therapeutic alternatives. 

“This study explores the functional relevance and therapeutic potential of FAAH inhibition combined with the proapoptotic activity of exogenous endocannabinoids on breast cancer survival.”

FAAH is an integral membrane enzyme that hydrolyzes endocannabinoids, rendering them inactive, and FAAH inhibition is predicted to increase cancer cell death. To test this, breast cancer cells were probed for FAAH expression using Western blot analysis, treated with FAAH inhibitors, exogenous endocannabinoids, and combinations of the two treatments, and assessed for viability. High levels of FAAH were observed in different breast cancer cell lines. 

FAAH inhibition was more effective than exogenous endocannabinoid treatment, and the combination of FAAH inhibitors and endocannabinoids was the most effective in inducing apoptosis of breast cancer cells in vitro. In addition, in vivo FAAH inhibition reduced breast cancer growth in immunodeficient mice. Further research exploring the therapeutic potential and impact of FAAH expression on cancer cells is warranted.

“FAAH inhibition is a promising approach, and tremendous progress has been made in the field to validate this mechanism as an alternative to chemotherapy.”

DOI - https://doi.org/10.18632/oncotarget.28534

Correspondence to - Chandra Mohan - cmohan@central.uh.edu

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Keywords - cancer, FAAH, breast cancer, cancer therapy, apoptosis

About Oncotarget 

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

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FAAH Inhibition Ameliorates Murine Breast Cancer

The fifth single by Wolves Of Oz, "Apoptosis" is available now on all streaming platforms.

℗ 2023 Apex Records

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LYRICS

Self-reflection
Not the mirror on the wall
Imperfections
Overanalyze every flaw

Self-destructive deception
Deadly conversations
Yeah, in my head
Might wind up dead
But that's not my intention

(Stay away)
You won't like what you find
Deep in the dark depths of my mind
The walls are closing in
I feel this is the end
Won't make it out alive

You should hear the things I say to myself
I wouldn't tell my enemy
I wouldn't tell my enemy
You should hear the things I say to myself
I'm my own worst enemy
I'm my own worst enemy

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(I'm my own worst enemy)

Self-inflicted perception
Sinking deeper my mind
Anchored to my vanity
Will I make it out alive

First in line to hate my rhymes
I don't know why I waste my time
I can't find happiness, I've tried
(Maybe I'm blind)

I should throw it all away
And find another field to grow in
I should give up on my dreams
Save my heart from being broken
Stop believing in myself
I'm not a diamond in the rough
Disappear into my doubts
Cause I'll never be enough

Every time I feel this way
I feel the weight of feeling wrong
Try to be myself today
But it won't stay that way for long
Introspective imperfections
Yeah, I see 'em all
Try to sing the pain away
But I just sing the same old song

Yeah
(You should hear the things I say...)

You should hear the things I say to myself
I wouldn't tell my enemy
I wouldn't tell my enemy
You should hear the things I say to myself
I'm my own worst enemy
I'm my own worst enemy

You should hear the things I say to myself
I wouldn't tell my enemy
I wouldn't tell my enemy
You should hear the things I say to myself
I'm my own worst enemy
I'm my own worst enemy

(I should throw it all away
And find another field to grow in
I should give up on my dreams
Save my heart from being broken
Stop believing in myself
I'm not a diamond in the rough
Disappear into my doubts
Cause I'll never be enough)

Apoptosis

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Apoptosis2

BUFFALO, NY- May 21, 2024 – A new research #paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 9, entitled, “Germicidal lamps using UV-C radiation may pose health safety issues: a biomolecular analysis of their effects on apoptosis and senescence.”

The battle against the COVID-19 pandemic has spurred a heightened state of vigilance in global healthcare, leading to the proliferation of diverse sanitization methods. Among these approaches, germicidal lamps utilizing ultraviolet (UV) rays, particularly UV-C (wavelength ranging from 280 to 100 nm), have gained prominence for domestic use. 

These light-emitting diode (LED) lamps are designed to sanitize the air, objects, and surfaces. However, the prevailing concern is that these UV lamps are often introduced into the market without adequate accompanying information to ensure their safe utilization. Importantly, exposure to absorbed UV light can potentially trigger adverse biological responses, encompassing cell death and senescence.

In this new study, researchers Nicola Alessio, Alessia Ambrosino, Andrea Boggi, Domenico Aprile, Iole Pinto, Giovanni Galano, Umberto Galderisi, and Giovanni Di Bernardo from the University of Campania Luigi Vanvitelli, Regional Public Health Laboratory in Siena, Italy, ASL Napoli 1 Centro P.S.I. Napoli Est-Barra, and Temple University performed a series of investigations aimed at comprehending the biological repercussions of UV-C radiation exposure from readily available domestic lamps. 

“Our focus centered on epithelial retinal cells, keratinocytes, and fibroblasts, components of the skin and ocular targets frequently exposed to UV irradiation.”

Their findings underscore the potential harm associated with even brief exposure to UV, leading to irreversible and detrimental alterations in both skin cells and retinal cells of the eye. Notably, epithelial retinal cells exhibited heightened sensitivity, marked by substantial apoptosis. In contrast, keratinocytes demonstrated resilience to apoptosis even at elevated UV doses, though they were prone to senescence. Meanwhile, fibroblasts displayed a gradual amplification of both senescence and apoptosis as radiation doses escalated.

“In summary, despite the potential benefits offered by UV-C in deactivating pathogens like SARS-CoV-2, it remains evident that the concurrent risks posed by UV-C to human health cannot be ignored.”

DOI - https://doi.org/10.18632/aging.205787

Corresponding authors - Umberto Galderisi - umberto.galderisi@unicampania.it, and Giovanni Di Bernardo - gianni.dibernardo@unicampania.it

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Keywords - aging, senescence, apoptosis, UV light, public health

About Aging-US

Aging publishes research papers in all fields of aging research, including but not limited to aging processes (from yeast to mammals), cellular senescence, age-related diseases (such as cancer and Alzheimer’s disease) and their prevention and treatment, anti-aging strategies and drug development, and, importantly, the role of signal transduction pathways in aging (such as mTOR) and potential approaches to modulate these signaling pathways to extend lifespan.

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Aging (Aging-US)

Germicidal Lamps Using UV-C Radiation May Pose Health Safety Issues

BUFFALO, NY- August 16, 2024 – A new #review was #published as the #cover paper of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), Volume 16, Issue 15, entitled, “Types of cell death and their relations to host immunological pathways”.

Various immune pathways in the host, such as TH1, TH2, TH3, TH9, TH17, TH22, TH1-like, and THαβ, have been identified. While TH2 and TH9 responses primarily target multicellular parasites, host immune pathways against viruses, intracellular microorganisms (like bacteria, protozoa, and fungi), and extracellular microorganisms utilize programmed cell death mechanisms to initiate immune responses and effectively eliminate pathogens.

In their review, researchers Kuo-Cheng Lu, Kuo-Wang Tsai, Yu-Kuen Wang, and Wan-Chung Hu from Taipei Tzu Chi Hospital, Fu Jen Catholic University, Taoyuan Armed Forces General Hospital, Tri-Service General Hospital and Ming Chuan University, reviewed these cell death pathways associated with the host immunological pathways.

"These relationships can help us understand the host defense mechanisms against invading pathogens and provide new insights for developing better therapeutic strategies against infections or autoimmune disorders.”

DOI - https://doi.org/10.18632/aging.206035

Corresponding authors - Wan-Chung Hu - Wanchung.Hu09@tzuchi.com.tw

Video short - https://www.youtube.com/watch?v=oPaevm0vpR8

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Keywords - aging, apoptosis, autophagy, ferroptosis, necroptosis, NETosis, pyroptosis

About Aging-US

The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population.

The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.)

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Cell Death Types and Their Relations to Host Immune Pathways

In this #review, #researchers explore the intricate relationship between various cell death pathways and host immunological responses.

Kuo-Cheng Lu, Kuo-Wang Tsai, Yu-Kuen Wang, and Wan-Chung Hu
from Taipei Tzu Chi Hospital, Fu Jen Catholic University, Taoyuan Armed Forces General Hospital, Tri-Service General Hospital and Ming Chuan University, have delved into the literature surrounding cell death pathways and their connections to host immunological pathways. 

Their review was published as the cover paper of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), Volume 16, Issue 15, entitled, “Types of Cell Death and Their Relations to Host Immunological Pathways.”

Full blog - https://aging-us.org/2024/08/exploring-links-between-cell-death-pathways-and-immune-responses/

Paper DOI - https://doi.org/10.18632/aging.206035

Corresponding author - Wan-Chung Hu - Wanchung.Hu09@tzuchi.com.tw

Video short - https://www.youtube.com/watch?v=oPaevm0vpR8

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Keywords - aging, apoptosis, autophagy, ferroptosis, necroptosis, NETosis, pyroptosis

About Aging-US

The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population.

The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.)

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Exploring Links Between Cell Death Pathways and Immune Responses

Apoptosis is a piece for percussion, live electronics, and video that explores the life cycle of a cell. In this context, the piece sonically narrates a body engaging in apoptosis.

Apoptosis (MIDI)

Do you have neanderthal DNA? Is your body your identity? What makes the knowledge of death possible when no one alive has experienced it first hand? How does dying feel? What are your schemas for understanding death? Is death the default, & it is life that happens occasionally? Does a cell know when it ought to die? When is an organism dead? When can we not dream? Can (certain) tissues and organs regenerate? What are the biochemical reactions a response to? What does oxygen do? Does the concept of death make control over others possible? Can we reverse death itself? What is the 'location' of a person? Do all cells come from other living cells? Or, can cells be created artificially from scratch? Is the body inferior to atman? Intrinsically, is everything conscious? Why do we see matter around if it's all one consciousness? Is Higg's boson dead? Do the cells need to divide to avoid death? Is dying like falling in deep sleep, & do we therefore die everyday? How does structure and order reproduce? What did you inherit from your mother at birth? Can dead mammoths be resurrected? &, will we have the power to create varied artificial life in the future with genome writing? SynTalk thinks about these & more questions using ideas from philosophy of science (Prof. G. Nagarjuna, IISER, Pune), theology (Swami Narasimhananda, Ramakrishna Mission Sevashrama, Kozhikode), & genomic sciences (Prof. Binay Panda, JNU, New Delhi).

#TDAG (The Dead And Gone) --- SynTalk

BUFFALO, NY - August 13, 2025 – A new #research paper was #published in Volume 16 of Oncotarget on July 29, 2025, titled “PCAIs stimulate MAPK, PI3K/AKT pathways and ROS-Mediated apoptosis in aromatase inhibitor-resistant breast cancer cells while disrupting actin filaments and focal adhesion.”

In this study, led by first author Jassy Mary S. Lazarte and corresponding author Nazarius S. Lamango from Florida A&M University College of Pharmacy and Pharmaceutical Sciences, researchers investigated a new class of compounds called polyisoprenylated cysteinyl amide inhibitors (PCAIs) as a potential treatment for aromatase inhibitor (AI) therapy resistant breast cancer. Aromatase inhibitors are a common treatment for estrogen receptor-positive (ER+) breast cancer, but many patients eventually develop resistance, leaving fewer therapeutic options.

The study focused on a PCAI compound called NSL-YHJ-2-27, which was tested in long-term letrozole-treated breast cancer cells (LTLT-Ca), an experimental model of AI therapy resistance. NSL-YHJ-2-27 activated two major signaling pathways, MAPK and PI3K/AKT. Although these pathways typically support cancer cell survival, their overstimulation by PCAIs led to increased oxidative stress, damaging the cells and inducing cell death by apoptosis. The compound also reduced levels of RAC1 and CDC42, proteins involved in maintaining cell shape and movement. These alterations resulted in cytoskeletal disruption and reduced structural integrity, making the cancer cells more vulnerable and less capable of spreading. Importantly, the effects of NSL-YHJ-2-27 persisted after the compound was removed, suggesting long-term control over AI resistant cancer cells may be possible.

“PCAIs inhibited cell proliferation and colony formation by 95% and 74%, respectively, increased active caspase 7 and BAX 1.5-fold and 56%, respectively. NSL-YHJ-2-27 (10 μM) induced LTLT-Ca spheroid degeneration by 61%.”

As a new class of targeted molecules, PCAIs represent an innovative approach distinct from traditional endocrine therapies. Their ability to affect multiple cellular mechanisms simultaneously makes them promising candidates for future drug development.

Overall, this study presents a promising new approach for treating AI therapy-resistant breast cancer. By targeting cellular pathways that support survival and mobility, PCAIs like NSL-YHJ-2-27 could provide a novel strategy to manage advanced or resistant forms of the disease. Further research, including in vivo studies and clinical trials, will be essential to confirm these findings and evaluate their therapeutic potential.

DOI - https://doi.org/10.18632/oncotarget.28759

Correspondence to - Nazarius S. Lamango - nazarius.lamango@famu.edu

Video short - https://www.youtube.com/watch?v=8xQEilloO9Q

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Keywords - cancer, PCAIs, ROS, MAPK, PI3K/AKT, LTLT-Ca cells

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New Compound Disrupts Survival Pathways in Aromatase Inhibitor-Resistant Breast Cancer Cells

Oncotarget is a primarily oncology-focused, peer-reviewed, open access journal. Papers are published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Oncotarget is now indexed by MEDLINE, PubMed and PMC/PubMed.

Read about the Oncotarget Scientific Integrity Process: https://www.oncotarget.com/scientific_integrity/

Aging-US is dedicated to advancing our understanding of the biological mechanisms that drive aging and the development of age-related diseases. Our mission is to serve as a platform for high-quality research that uncovers the cellular, molecular, and systemic processes underlying aging, and translates these insights into strategies to extend healthspan and delay the onset of chronic disease.

Read about the Aging (Aging-US) Scientific Integrity Process: https://aging-us.com/scientific-integrity

f(q) = Is soil a definitive sign of life? (#TCAFG)

SynTalk is a freewheeling interdisciplinary talk show with a philosophical approach to understanding the world from a long term perspective.

By fusing elements of metal, r&b, pop, hip-hop and jazz, Wolves Of Oz set themselves apart as one of the more unique bands in the Knoxville, TN area. 

With a multi-talented line-up of musicians, WOz takes listeners on a compelling journey, blending their sound with melodic hooks of relatable experiences.

With influences ranging from Issues, Periphery and Linkin Park to Usher, The Weeknd and Post Malone, this is a band you will definitely want to keep on your radar.


New tracks tagged #Apoptosis