BUFFALO, NY- November 8, 2023 – A new #researchpaper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 20, entitled, “Tissue immunoexpression of IL-6 and IL-18 in aging men with BPH and MetS and their relationship with lipid parameters and gut microbiota-derived short chain fatty acids.”

Recent studies indicate that inflammation is one of the causes of the development of benign prostatic hyperplasia (BPH). Inflammation may result from past infections, metabolic disorders, but also from the state of functioning of the intestinal microbiota. 

In this new study, researchers Weronika Ratajczak, Maria Laszczyńska, Aleksandra Rył, Barbara Dołęgowska, Olimpia Sipak, Ewa Stachowska, Marcin Słojewski, and Anna Lubkowska from Poland’s Pomeranian Medical University and State University of Applied Sciences aimed to assess whether the diagnostic lipid parameters for metabolic syndrome and short-chain fatty acids (SCFAs) are related to the immunoexpression of interleukins in prostate tissue with benign hyperplasia. The study involved 103 men with BPH, who were divided into two groups depending on the presence of MetS. 

“We analysed tissue immunoexpression of two proinflammatory interleukins: IL-6, which is known to be involved in the development of BPH, and IL-18, which has not been analysed so far.”

The results of their study indicated that men with BPH + MetS in the stroma of the prostate have a significantly higher overall percentage of IL-6+ cells compared to men without MetS (p = 0.034). The analysis of IL-18 immunoexpression in prostate tissue indicated that in men with BPH + MetS, the glandular part of the prostate had a significantly higher percentage of cells with strong IL-18 expression (p = 0.040). They also noticed a relationship between tissue expression of IL-6 and IL-18 and lipid parameters (TG and HDL). 

“We conclude that lipid disorders occurring in men with BPH increase inflammation in the prostate gland. Moreover, it has also been demonstrated for the first time that, indirectly, through SCFAs, the gut microbiota can act to prevent or create an inflammatory microenvironment in the prostate gland.”

DOI - https://doi.org/10.18632/aging.205091

Corresponding author - Anna Lubkowska - anna.lubkowska@pum.edu.pl

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Keywords - aging, benign prostatic hyperplasia (BPH), metabolic syndrome (MetS), lipids, interleukin 6 (IL-6), interleukin 18 (IL-18), short-chain fatty acids

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

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A New Connection Between The Gut Microbiota and Prostate Inflammation in Aging Men

CiiRadio - Nurul Khair - Dr Dawid Johan Mouton Dicusses BPH

26-11-23 Nurul Khair - Dr Dawid Johan Mouton Dicusses BPH

Compare Prostate SP and VigRX Prostate Support, two popular supplements for prostate health. Discover their ingredients, benefits, and which offers superior support for urinary function and prostate discomfort.

Read more: https://www.prostatesp.com/blogs/supplements/prostatesp-vs-vigrx-prostate-support

Prostate SP Vs VigRX Prostate Support Review

Explore the potential benefits of saw palmetto for prostate health, including support for urinary function and reduction of BPH symptoms. Learn about its role in maintaining healthy prostate size and function.

Read more: https://www.prostatesp.com/blogs/nutrition/saw-palmetto-for-prostate

Saw Palmetto for Prostate Health?

Learn how an enlarged prostate (BPH) can impact men's sexual health, causing erectile dysfunction and reduced libido, and explore treatment options to improve well-being.

Read More: https://www.prostatesp.com/blogs/sexual-health/sexual-effect-of-enlarged-prostate-on-men

How Does an Enlarged Prostate Impact a Man's Sexual Health?

Part of the BURST/BJUI podcast series.

In this podcast, Mr Feroz Ali Khan, Urology Registrar, Northampton General Hospital, talks about the BJUI Knowledge module "Who can we predict is going to have progression of BPH/LUTS”.

You can visit BJUI Knowledge here
https://bjuiknowledge.bjuinternational.com/

BJUI/BURST: Risk Of LUTS Progression

BUFFALO, NY — February 19, 2025 — A new #research paper was #published by Aging (Aging-US) on January 6, 2025, in Volume 17, Issue 1, titled “The profile of oxidative stress markers (arachidonic and linoleic acid derivatives) in patients with benign prostatic hyperplasia in relation to metabolic syndrome.”

A team of researchers, led by first author Weronika Ratajczak and corresponding author Olimpia Sipak from Pomeranian Medical University, examined how inflammation and metabolic health contribute to benign prostatic hyperplasia (BPH), a common condition that causes prostate enlargement in aging men, leading to urinary problems. Their findings suggest that inflammatory-related molecules in the blood may play a key role in BPH development, especially in men with metabolic syndrome—a group of conditions including obesity, high blood sugar, and high cholesterol.

BPH affects millions of men as they age, making urination more difficult and sometimes painful. While age and hormonal changes are known factors, the precise causes of prostate enlargement remain unclear. This study provides new evidence that inflammation, especially lipid-derived inflammatory markers, may be a driving factor behind BPH, particularly in those with poor metabolic health.

The research team analyzed blood samples from 219 men, including 144 with BPH and 75 without, measuring markers related to inflammation and oxidative stress. The results showed that men with BPH had significantly higher levels of pro-inflammatory molecules such as 12S-HETE and 5-HETE while having lower levels of anti-inflammatory substances like lipoxin A4. The imbalance was even more pronounced in men with both BPH and metabolic syndrome, indicating a possible link between poor metabolic health and worsening prostate conditions​.

“Furthermore, there is mounting evidence that links the onset of inflammation with the development of prostate diseases, including benign prostatic hyperplasia and prostate cancer.”

Metabolic dysfunction and chronic inflammation may not only contribute to BPH development but also exacerbate its severity. Monitoring metabolic health could play a role in reducing the risk of prostate enlargement.

Future research is needed and may focus on whether anti-inflammatory treatments or lifestyle changes—such as improved diet, weight management, and exercise—could help slow the progression of BPH or reduce its symptoms​.

DOI - https://doi.org/10.18632/aging.206187

Corresponding author - Olimpia Sipak - olimpiasipak-szmigiel@wp.pl

Video short - https://www.youtube.com/watch?v=O0VMvqaVsUs

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Keywords - aging, benign prostatic hyperplasia (BPH), metabolic syndrome (MetS), lipid markers, inflammation, fatty acids derivatives

About Aging-US

The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population.

The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.)

Please visit our website at https://www.Aging-US.com​​ and connect with us:

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Inflammation and Metabolic Syndrome Linked to Benign Prostatic Hyperplasia

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Dans ce premier épisode de CTRL+S le podcast du BPH pour comprendre, prévenir et soigner, on explore les liens entre la santé mentale et la santé numérique.
Au programme :
Les chatbots sont-ils une aide ou un risque pour le bien-être des jeunes ?


La réalité augmentée peut-elle soigner certains troubles psychiques ?


L’intelligence artificielle va-t-elle remplacer l’humain pour soigner les maladies mentales ?


Nos données personnelles sont-elles bien protégées ?


Pour en parler, nous recevons trois expertes : 
- Melissa Macalli – Chercheuse en Santé Publique & Épidémiologiste (BPH, Inserm, Université de Bordeaux) 
- Hélène Sauzéon – Professeure en Psychologie et Sciences Cognitives (Inria, BPH, Université de Bordeaux) 
- Marie Navarro – Post-doctorante en Santé Publique et Biostatistique (Université de Groningen)
Un épisode essentiel pour mieux comprendre comment le numérique transforme la recherche en santé mentale, mais aussi ses limites.

Nouvelles technologies - prévention ou danger ?

https://smartypance.com/the-daily-pance-and-panre-question-35/

The Daily PANCE And PANRE (Questions 30 - 60) #5 - BPH

Bienvenue dans CTRL+S, le podcast du centre de recherche en santé publique Bordeaux Population Health.

Ici on à créé un espace de discussion autour des différentes thématiques de santé publique.
Dans chaque épisode, les chercheurs et chercheuses de notre centre de recherche, mais aussi de nos partenaires, répondent aux questions du grand public pour éclairer des sujets qui, bien que présents dans notre quotidien, restent encore flous. 

Alors, bienvenue dans les coulisses de la recherche en santé publique et bonne exploration.

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Aging-US is dedicated to advancing our understanding of the biological mechanisms that drive aging and the development of age-related diseases. Our mission is to serve as a platform for high-quality research that uncovers the cellular, molecular, and systemic processes underlying aging, and translates these insights into strategies to extend healthspan and delay the onset of chronic disease.

Read about the Aging (Aging-US) Scientific Integrity Process: https://aging-us.com/scientific-integrity

BJUI aims to provide the very highest standard of research and clinical information for the urological community, promoting awareness of new advances and supporting best practice in urology.

The journal publishes original articles, reviews, comments and educational articles. Clinical relevance is critical and the journal covers the entire breadth of urology under the following sections: Comments, Reviews, Urological Oncology (all areas of urological oncology as well as recent advances in diagnostic techniques), Robotics and Laparoscopy, Upper Urinary Tract, Functional Urology, Andrology, Translational Science and Professional Innovation.

BJUI is constantly innovating to provide the urology community with a journal that is fresh in appearance and easy to read.

PANCE, PANRE, and End of Rotation (EOR) Exam Review. Don't study harder, study smarter: https://smartypance.com/

New tracks tagged #BPH