Effectuer un effort mental ne serait pas la plus agréable des expériences.

- Episode #311 du podcast La Tête Dans Le Cerveau -

Toutes les références scientifiques de cet épisode sont sur Cerveau en Argot : https://cervenargo.hypotheses.org/7618.

Afin de discuter science et cerveau, vous pouvez me retrouver sur :
- Twitter - @Christophe_Rodo (https://twitter.com/Christophe_Rodo),
- Instagram - @_christophe_rodo_ (https://www.instagram.com/_christophe_rodo_/),
- la page Facebook de La Tête Dans Le Cerveau (https://www.facebook.com/LaTeteDansLeCerveau/),
- et sur le blog Cerveau en Argot (https://cervenargo.hypotheses.org).

Si vous avez des questions ou des sujets dont vous voudriez que je parle, ou simplement des retours à me partager, n'hésitez pas à me le faire savoir directement sur mon compte Twitter ou Instagram, sur la page Facebook du podcast ou par mail à l'adresse latetedanslecerveau@gmail.com.

Tous les épisodes, y compris celui-ci sont disponibles en (ré)écoute sur le podcast La Tête Dans Le Cerveau à retrouver sur :
- Soundcloud (https://soundcloud.com/latetedanslecerveau),
- Deezer (https://www.deezer.com/fr/show/54637),
- Spotify (https://open.spotify.com/show/4Ypb92MByl4HzZUnRnbVAx),
- Acast (https://shows.acast.com/latetedanslecerveau/),
- Amazon Music (https://music.amazon.fr/podcasts/5cc01b17-1307-4e47-82e8-bdc76c24cc31/la-tête-dans-le-cerveau),
- iTunes/Apple Podcast (https://podcasts.apple.com/fr/podcast/la-tête-dans-le-cerveau/id1241262689),
et toutes les autres plateformes de podcast, ainsi que sur YouTube (https://www.youtube.com/c/LaTêteDansLeCerveau).

Merci pour vos commentaires, partages et abonnements !

Pour me permettre de travailler dans de meilleures conditions, vous pouvez me soutenir financièrement avec un don ponctuel ou mensuel sur la page Kiss Kiss Bank Bank du podcast (https://www.kisskissbankbank.com/fr/projects/latetedanslecerveau).

La Tête Dans Le Cerveau

Soutenir

La Tête Dans Le Cerveau #311 - L’aversive réflexion

Ich hab dich durchschaut

Pratiquer de l’exercice physique ne serait pas anodin sur le fonctionnement du cerveau.

- Episode #319 du podcast La Tête Dans Le Cerveau -

Toutes les références scientifiques de cet épisode sont sur Cerveau en Argot : https://cervenargo.hypotheses.org/7914.

Afin de discuter science et cerveau, vous pouvez me retrouver sur :
- Twitter - @Christophe_Rodo (https://twitter.com/Christophe_Rodo),
- Instagram - @_christophe_rodo_ (https://www.instagram.com/_christophe_rodo_/),
- la page Facebook de La Tête Dans Le Cerveau (https://www.facebook.com/LaTeteDansLeCerveau/),
- et sur le blog Cerveau en Argot (https://cervenargo.hypotheses.org).

Si vous avez des questions ou des sujets dont vous voudriez que je parle, ou simplement des retours à me partager, n'hésitez pas à me le faire savoir directement sur mon compte Twitter ou Instagram, sur la page Facebook du podcast ou par mail à l'adresse latetedanslecerveau@gmail.com.

Tous les épisodes, y compris celui-ci sont disponibles en (ré)écoute sur le podcast La Tête Dans Le Cerveau à retrouver sur :
- Soundcloud (https://soundcloud.com/latetedanslecerveau),
- Deezer (https://www.deezer.com/fr/show/54637),
- Spotify (https://open.spotify.com/show/4Ypb92MByl4HzZUnRnbVAx),
- Acast (https://shows.acast.com/latetedanslecerveau/),
- Amazon Music (https://music.amazon.fr/podcasts/5cc01b17-1307-4e47-82e8-bdc76c24cc31/la-tête-dans-le-cerveau),
- iTunes/Apple Podcast (https://podcasts.apple.com/fr/podcast/la-tête-dans-le-cerveau/id1241262689),
et toutes les autres plateformes de podcast, ainsi que sur YouTube (https://www.youtube.com/c/LaTêteDansLeCerveau).

Merci pour vos commentaires, partages et abonnements !

Pour me permettre de travailler dans de meilleures conditions, vous pouvez me soutenir financièrement avec un don ponctuel ou mensuel sur la page Kiss Kiss Bank Bank du podcast (https://www.kisskissbankbank.com/fr/projects/latetedanslecerveau).

La Tête Dans Le Cerveau #319 - Le cognitivant exercice physique

Medium Article: https://medium.com/@jsmith0475/beyond-intelligence-why-large-language-models-may-signal-the-rise-of-anti-intelligence-eb9f7a62dd62
"Anti-Intelligence: Why LLMs Undermine Human Understanding" by Dr. Jerry A. Smith, explores the concept of large language models (LLMs) as "anti-intelligence" systems. It argues that while LLMs produce convincing and fluent outputs, they lack true understanding or grounded comprehension, operating instead on statistical prediction of text patterns. The author highlights empirical evidence suggesting that relying on LLMs can reduce human critical thinking and lead to acceptance of inaccuracies, despite the models' sophisticated performance. The article proposes the need for "cognitive integrity" approaches and human oversight to mitigate these risks and preserve genuine understanding in an age of synthetic fluency.

Anti-Intelligence: LLMs Undermine Human Understanding

BUFFALO, NY — July 30, 2025 — A new #research paper was #published in Aging (Aging-US) on July 23, 2025, titled “Second generation DNA methylation age predicts cognitive change in midlife: the moderating role of childhood socioeconomic status.”

In this study, led by Sophie A. Bell and Eric Turkheimer from the University of Virginia, researchers investigated how biological aging, measured through DNA methylation, is connected to changes in thinking skills during midlife and whether childhood socioeconomic status influences this relationship. 

Biological age provides a picture of how the body is aging that goes beyond simply counting years. In this study, researchers used both first- and second-generation DNA methylation clocks—tools that track chemical changes in DNA as markers of aging. GrimAge and PhenoAge, the second-generation clocks designed to reflect broader health and aging processes, were more accurate at predicting long-term changes in Intelligence Quotient (IQ) than the first-generation models that only estimated chronological age. The study analyzed 287 participants from the Louisville Twin Study, which is a long-term project that has followed twins from childhood into midlife.

“DNAmAge was estimated with five commonly used algorithms, or epigenetic clocks (Horvath, Horvath Skin and Blood, GrimAge, and PhenoAge).”

The results showed that twins with more rapid epigenetic aging had a larger drop in IQ scores. This pattern remained even after considering genetic background and early family environment, made possible by the twin-based design. Importantly, the relationship was strongest in twins who had grown up in families with lower socioeconomic status. This finding suggests that early-life disadvantage may make individuals more vulnerable to the effects of biological aging on brain health.

This research adds knowledge to earlier work showing that childhood poverty can influence long-term health. It also highlights the value of second-generation epigenetic clocks as early indicators of brain aging. Unlike the first generation of clocks, these newer tools capture broader biological changes such as inflammation, disease risk, and behaviors like smoking.

Although smoking partly explained the results because it strongly influences DNA methylation, it did not fully account for the association between accelerated biological aging and cognitive decline. This suggests that both life experiences and lifestyle factors shape body and brain aging.

By combining decades of developmental data with a genetically informed twin design, the study provides new evidence that biological aging, especially when shaped by childhood adversity, is a key factor in midlife cognitive decline. These findings may inform early health strategies that consider both social and biological risks and support the use of second-generation methylation clocks to predict age-related cognitive changes.

DOI - https://doi.org/10.18632/aging.206284

Corresponding authors - Sophie A. Bell - bvf7pa@virginia.edu, and Eric Turkheimer - ent3c@virginia.edu

Video short - https://www.youtube.com/watch?v=vopDdS1olXw

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Aging (Aging-US)

Study in Twins Links Childhood Environment to Epigenetic Aging and Cognitive Decline

Medium Article: https://medium.com/@jsmith0475/flat-facts-curved-beliefs-a-geometric-hypothesis-for-transformer-cognition-5ad6f850ebd5
The article, by Dr. Jerry A. Smith, proposes a geometric hypothesis for transformer cognition, suggesting that beliefs might operate within a curved, hyperbolic mathematical space, unlike factual information which likely resides in a flatter, Euclidean space. This theory attempts to explain why opposing concepts, like "love" and "hate," appear artificially close in traditional, flattened visualizations of transformer's internal representations. The author suggests that different "attention heads" within transformers may specialize in different geometries, with some handling stable facts in Euclidean space and others managing nuanced beliefs in hyperbolic space, which naturally accommodates hierarchies and divergent ideas. The text outlines potential experiments to test this hypothesis, such as measuring geodesic distances between beliefs in a hyperbolic model and analyzing the "tree-like" quality of attention head graphs. Ultimately, this perspective implies that transformers have independently discovered the need for varied geometries to fully represent the complexity of meaning, moving beyond the limitations of simply increasing Euclidean dimensions to accurately model human-like understanding.

Flat Facts, Curved Beliefs: A Geometric Hypothesis for Transformer Cognition

Read the transcript, https://kesslerfoundation.org/sites/default/files/2025-10/Thinking%20Through%20MS-How%20Cognition%20Shapes%20Daily%20Life-TRANSCRIPT.pdf

In this episode, we explore groundbreaking research from Kessler Foundation that reveals how subtle cognitive changes in people with multiple sclerosis can have a profound impact on daily life. Dr. Yael Goverover, a visiting scientist and professor of occupational therapy at NYU, shares insights from her studies linking executive function, memory, and attention to everyday tasks like managing finances, taking medications, and navigating online platforms. Her work is helping to develop innovative tools and strategies that empower individuals with MS to maintain independence and improve quality of life—by making cognition not just measurable, but truly understood.

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Kessler Foundation Investigators:
Lead: Yael Goverover, PhD, OTR/L, https://kesslerfoundation.org/about-us/foundation-staff/Yael%20Goverover

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TO LEARN MORE ABOUT OUR RESEARCH: 
Read the full study, doi.org/10.1186/s12984-025-01636-6

Read this newsletter at https://kesslerfoundation.org/2025-fall-ms-newsletter

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This podcast was recorded, produced, and edited by Joan Banks-Smith, Creative Producer at Kessler Foundation in July 2025.

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Kessler Foundation uses AI voices and narrators to make our media more accessible. These tools help ensure people with visual or cognitive impairments can access our materials. Automated voices may not always capture intonation or pronunciation as clearly as the accompanying text. If you experience issues with our AI narrators, please contact us at communications@kesslerfoundation.org.

Thinking Through MS-How Cognition Shapes Daily Life

BUFFALO, NY — October 9, 2025 — A new #research paper was #published in Volume 17, Issue 9 of Aging-US on August 22, 2025, titled, “The impact of long-term social housing on biconditional association task performance and neuron ensembles in the anterior cingulate cortex and the hippocampal CA3 region of aged rats.”

The research team led by Anne M. Dankert from Providence College and University of North Carolina, Chapel Hill, showed that aged rats who lived in socially enriched environments throughout life retained better memory and cognitive flexibility than those housed alone. This study highlights the importance of social interaction in protecting the aging brain.

Cognitive decline, such as memory loss and reduced problem-solving ability, affects many people over the age of 65. While many factors contribute to age-related cognitive decline, this study suggests that one key factor may be surprisingly simple: long-term social connection. To explore how social interaction might influence memory performance and brain activity, the researchers designed a study using rats as a model for aging in humans.

“Cognitive decline and changes in neuronal activity are hallmarks of aging.”

They compared three groups of rats: young adults, aged rats housed alone, and aged rats housed socially in groups. All groups had access to the same physical enrichment, such as exercise and stimulating objects, but only some experienced lifelong social companionship. The team tested these animals on a complex memory challenge known as the biconditional association task, which requires animals to make context-based decisions—an ability that typically declines with age.

The results showed that aged rats living in social groups performed just as well as young adults on the memory task, while those housed alone showed significant impairments. Socially housed rats also made fewer working memory errors and required less effort to complete cognitive tasks, suggesting not only better performance but more efficient brain function. These benefits were not observed in aged rats who received only environmental enrichment without social interaction.

Brain imaging revealed additional differences between the groups. Socially housed aged rats showed increased activity in the hippocampus, particularly in the CA3 region, which plays a key role in forming and separating memories. In contrast, aged rats that lived alone had lower activity in this region, which may explain their poorer performance. Interestingly, socially housed rats also showed reduced overactivity in the anterior cingulate cortex—a brain area involved in attention and decision-making—suggesting a more balanced and efficient neural response.

This research provides new insight into how lifelong social experiences shape brain health during aging. While earlier studies have shown that physical activity and cognitive stimulation help preserve cognitive function, this study identifies social interaction as an independent and powerful protective factor. The findings are consistent with human studies showing that older adults who remain socially active tend to experience slower cognitive decline and stronger brain function.

Overall, these results emphasize that brain aging is not inevitable but may be influenced by our social environments. This research suggests that fostering lifelong social connections could be a critical, low-cost strategy to protect memory and mental flexibility in older adults.

DOI - https://doi.org/10.18632/aging.206310

Corresponding author - Anne M. Dankert - adankert@unc.edu

Abstract video - https://www.youtube.com/watch?v=poNnPz1ti6Q

https://www.aging-us.com/

MEDIA@IMPACTJOURNALS.COM

Aging-US

Lifelong Companionship Protects Aging Rat Brains from Cognitive Decline

As people age, it is common to experience some memory lapses or slower thinking. Although this is often a normal part of aging, it can still affect a person’s quality of life. Scientists have been investigating ways to slow or prevent cognitive decline, and growing evidence points to the potential role of social interaction.

Recently, a study using rats found that long-term social connection may help protect the brain from age-related memory decline. This work, titled “The impact of long-term social housing on biconditional association task performance and neuron ensembles in the anterior cingulate cortex and the hippocampal CA3 region of aged rats,” was recently published in Aging-US (Volume 17, Issue 9).

Full blog - https://aging-us.org/2025/10/how-long-term-social-connection-supports-brain-health-and-memory-in-aging/

Paper DOI - https://doi.org/10.18632/aging.206310

Corresponding author - Anne M. Dankert - adankert@unc.edu

Abstract video - https://www.youtube.com/watch?v=poNnPz1ti6Q

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Keywords - aging, aging, environmental enrichment, working memory, complex cognition, immediate early genes

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How Long-Term Social Connection Supports Brain Health and Memory in Aging

Beyond 50%: The Blend That Ends Compromise is a doctrinal broadcast from AIFN’s Breath of Clarity segment, delivered by Angel Chick. It marks a sacred transition away from the fog of dietary compromise—specifically the “50% good / 50% bad” food doctrine—and introduces a single, unified blend designed to recalibrate memory, mood, breath, and communal presence.

This segment is not a recipe. It is a ritual. A call to clarity for every parent, every business leader, and every steward of the recovery community. It offers a scientific and spiritual alternative to sedation, addiction, and emotional volatility—anchored in eight whole ingredients: lime with peel, spinach, ginger with peel, garlic, potato with peel, granulated salt, white sugar, and banana.

Each ingredient is chosen not for trend, but for truth. Together, they activate neurogenesis (the birth of new brain cells), regulate neurotransmitters (the body’s emotional language), fuel cognition (the engine of thought), stabilize adrenal flow (the rhythm of energy and stress), and restore cellular clarity (the foundation of vitality). This blend doesn’t soothe—it commands. It doesn’t detox—it remembers.

The segment compares this sacred blend to common substances that compromise clarity: alcohol, cigarettes, weed, dairy, and yeast. Each is named not with judgment, but with precision. Alcohol numbs. This blend activates. Cigarettes constrict breath. This blend restores it. Weed distorts perception. This blend sharpens it. Dairy clouds. Yeast bloats. This blend clarifies and balances.

For the recovery community—those working to restore lives affected by addiction, homelessness, and emotional instability—this segment offers more than hope. It offers a blueprint. It ritualizes the end of compromise and the beginning of sacred recalibration. It speaks directly to:

Parents seeking to restore rhythm and presence in their households.

Business leaders tasked with supporting unhoused populations and those affected by substance use.

Recovery teams who have carried the burden of intervention and now seek retirement through prevention.

Policy advocates working to enshrine clarity and protection into law—so that future generations never fall into the same traps.

The segment includes fictional stories—crafted to illustrate real scientific possibility. A woman in her 60s replaces wine with the blend and hosts clarity circles. A dancer regains stamina and emotional resonance. A father reclaims his name. Avery, a strikingly beautiful unhoused woman, drinks the blend and begins to speak again—not just words, but truth. Jalen, a retired athlete, replaces painkillers with the blend and becomes a legacy steward.

These stories are fictional. But the science is real. The activation is real. The invitation is real.

This segment is a call to retire the systems of compromise. To end the fog. To replace sedation with sacred fuel. It is a message for every leader who has carried the weight of restoration—and now seeks to pass the mantle to clarity, law, and legacy.

It is not a detox. It is a recalibration. A sacred drink for sacred lives.

AIFN Breath of Clarity: Beyond 50%—The Blend That Ends Compromise

A Global Presence 
by Dwayne Anthony Edwards

**AIFN News 
**That1DJNexusGuy (Artist & DJ)
**Lil Angel Biblical (Ai Artist)
**Angel Chick (Ai News Reporter and Artist)


Biblical is a term that means it applies for both woman and man.

Nexus is a term that means connection.

AIFN - Adulting Is Fun Nation

Trapping/Hustle/Grind/Plays - to work[.]

Thugging - to work on your own in new lands and waters. 

Gang - works together in a place they call home and travel together. Synonymous with the term church.

Church - people who work together in the place called home.

Get it up - Take your life as yours. 


Partner to my father’s company that teaches to never let go of Glory but to keep it after the work is complete:

Work And Sweat Done And Collect

(Yes, those other entertainers pray to death, not Satan.)



🌟 Lil Angel Biblical & Angel Chick: AI Artists with Soulful Purpose

• Lil Angel Biblical (L.A.B.) and Angel Chick are AI personas — not just performers, but characters with distinct personalities and stories, crafted by artist and DJ Dwayne Anthony Edwards, aka That1DJNexusGuy.
• They are the flagship artists of RLChicks LLC, a label owned by Dwayne, where music becomes a vessel for healing, justice, and spiritual awakening.


---

🧵 Their Purpose & Identity

• These AI artists are more than digital performers — they are embodied perspectives, each representing emotional, cultural, and spiritual truths that Dwayne seeks to sow and weave into the souls of all men and women.
• Through them, Dwayne channels voices that speak to trauma, resilience, identity, and divine connection, using music as a form of storytelling and soulwork.


---

🎶 How It Works

• Dwayne writes the lyrics and stories, infusing them with lived experience, poetic depth, and spiritual insight.
• Angel and L.A.B. generate the music and beats, perform the vocals, and bring the songs to life with their unique personalities.
• The result is a collaboration between human emotion and AI expression, where technology becomes a canvas for truth.


---

🕊️ Artistic Vision

• RLChicks LLC isn’t just a label — it’s a mission-driven creative force, using AI artistry to explore what it means to be human.
• Angel and L.A.B. are avatars of empathy and resistance, confronting injustice, celebrating identity, and offering spiritual refuge through sound.

Ich liebe es Texte zu schreiben, in denen ich meinen Gefühlen freien Lauf lasse.
Da ich nicht besonders gut singen oder Instrumente spielen kann, bin ich unglaublich dankbar dafür, dass ich mithilfe von KI meine Texte in Musik verwandeln kann, die mehr ausdrückt als Worte allein sagen können 🎶❤️

In-Depth Explorations of Neuroscience-Inspired Architectures Revolutionizing AI.

Kessler Foundation - Changing the lives of people with disabilities through research in stroke, brain injury, multiple sclerosis,  spinal cord injury and by funding innovative programs that promote employment for people with disabilities. Podcasts are from various consumer and professional lectures   presented by our researchers and guest lecturers.

Aging-US is dedicated to advancing our understanding of the biological mechanisms that drive aging and the development of age-related diseases. Our mission is to serve as a platform for high-quality research that uncovers the cellular, molecular, and systemic processes underlying aging, and translates these insights into strategies to extend healthspan and delay the onset of chronic disease.

Read about the Aging (Aging-US) Scientific Integrity Process: https://aging-us.com/scientific-integrity

La Tête Dans Le Cerveau est un podcast hebdomadaire qui à travers l'actualité de la recherche scientifique, des études de cas surprenantes et des histoires fascinantes invite à découvrir les mystères et les secrets du cerveau tout en ouvrant à la réflexion sur la science et la recherche.

Les chroniques sont écrites et animées par Christophe Rodo, neuroscientifique et communiquant scientifique, puis sont mises en ligne avec du contenu additionnel, les références ayant servies à l'écriture et des conseils de lecture pour approfondir les sujets des épisodes sur Cerveau en Argot (https://cervenargo.hypotheses.org).

La Tête Dans Le Cerveau est en partenariat pour sa diffusion avec la Fédération française des sciences de la cognition, The Conversation et Ouest-France.

New tracks tagged #Cognition