FULL TEXT - https://www.drjjamesfrost.com/post/intrinsic-cellular-computation-far-reaching-implications-for-solving-the-cancer-problem

In my article Cancer’s Intelligence I conjectured that cancer is able to compute survival solutions to future environmental changes that it has not yet encountered. That is, that cancer can predict the future and ready itself to adapt to new, yet unseen environmental conditions, whether a change in oxygen tension or a chemotherapeutic drug.

A recent, exceedingly relevant paper entitled Trade-offs between cost and information in cellular prediction by Tjalma et al analyzes cellular adaptation and lays out the conditions for prediction of a survival response to an adverse environmental change. The cellular response is an intrinsically computed solution to future external events using the cell’s internal computational machinery. Historically, it has been thought that only higher organisms “can predict the future environment and initiate a response ahead of time”, but this is not the case.

At bottom, energy and time are two key computational limits. Energy (free energy) for computation, storing information, and the protein synthesis needed for future actions limits computation of the optimal solution for future survival moves.  Time is a factor in computing solutions and a in sensing and sampling the current and past environments sufficiently finely for accurate predictions. Optimal time averaging for the cell is key, which also has the advantage of filtering noise.

The Tjalma article elucidates the informational bounds a cell can possibly have about the future. The costs of a bit of informational sampling and processing are computed and compared.  As information-processing humans, we extract only the most useful information from the past environment as we plan future actions – the cell does the same. How and under what conditions a cell approaches the information bound for its internal computation is examined in detail by exploring Markovian and non-Markovian models and by examining the necessary fineness of temporal sampling of the environment and the cell’s computational speed. The information bottleneck theory is key in this analysis, as it dictates information compression for storage and its costs.

The article is a challenging, yet rewarding read and one that is intimately related to the vast computation ability of the cancer cell and more importantly, cancer cell networks. In a way, this article is the missing link between cancer’s computation from instantaneous, present environmental conditions – the constrained regime held by most cancer biologists – to the tracking and selective sampling of the past and the present to the response to yet-unseen future events – just as human and higher animal computation occurs.

For more information on the molecular imaging aspects of cancer characterization, treatment, and monitoring, please visit BioMolecular Imaging, LLC http://biomolecularimaging.com

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Intrinsic Cellular Computation: Far Reaching Implications for Solving the Cancer Problem

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[Pre-Chorus]
They say, "Don't live in shadows," but it's where I hide,
Can’t feel my heartbeat, in the night we confide.
Sipping on sorrow, it's a bitter blend,
Trying to feel tomorrow, but the nights never end.

[Chorus]
I fly too close to the sun, yet I'm cold inside,
Burning on these memories I can’t leave behind.
Dancing with my demons, they know how I move,
Lost in the rhythm, trying to find my groove.
[Verse 1]
In the rearview, my dreams look faded,
Gone in the smoke, hearts so jaded.
Streets whisper secrets in every car,
Chasing the sunrise, feels so far.

Mama said, "Don't fly too high,"
But I spread my wings, touch the sky.
Burning bright, even when I'm scared,
Life ain't fair, but I'm prepared.

[Pre-Chorus]
They say, "Don't live in shadows," but it's where I hide,
Can’t feel my heartbeat, in the night we confide.
Sipping on sorrow, it's a bitter blend,
Trying to feel tomorrow, but the nights never end.

[Chorus]
I fly too close to the sun, yet I'm cold inside,
Burning on these memories I can’t leave behind.
Dancing with my demons, they know how I move,
Lost in the rhythm, trying to find my groove.
[Bridge]
Maybe in another life, I'd find the light,
Drown out the noise, hold onto what’s right.
But tonight, I'll let the stars fade out of view,
In the echoes of the silence, I’ll search for you.

[Chorus]
I fly too close to the sun, yet I'm cold inside,
Burning on these memories I can’t leave behind.
Dancing with my demons, they know how I move,
Lost in the rhythm, trying to find my groove.
[Verse 2]
Rollin' through the city with my heart on my sleeve,
Battling my demons, trying to believe.
Every step I take, shadows in the night,
Looking for the light, trying to make it right.

Voices in my head, tellin' me to give in,
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But I keep pushing forward, time after time.
[Pre-Chorus]
They say, "Don't live in shadows," but it's where I hide,
Can’t feel my heartbeat, in the night we confide.
Sipping on sorrow, it's a bitter blend,
Trying to feel tomorrow, but the nights never end.

[Chorus]
I fly too close to the sun, yet I'm cold inside,
Burning on these memories I can’t leave behind.
Dancing with my demons, they know how I move,
Lost in the rhythm, trying to find my groove.
[Bridge]
Maybe in another life, I'd find the light,
Drown out the noise, hold onto what’s right.
But tonight, I'll let the stars fade out of view,
In the echoes of the silence, I’ll search for you.

[Chorus]
I fly too close to the sun, yet I'm cold inside,
Burning on these memories I can’t leave behind.
Dancing with my demons, they know how I move,
Lost in the rhythm, trying to find my groove.

[Outro]
So here’s to the nights we can’t forget,
To the lost dreams and the deep regrets.
Playing our song on the radio loud,
Lost in the beat, just another face in the crowd.

Too Close To The Sun (Extended)

"Skybound Horizons" ignites the thrill of speed and adrenaline with its racing drum and bass beats. This track propels you forward with relentless energy, echoing the pulse-pounding intensity of a high-speed chase through the skies. Accelerate through each dynamic rhythm and bassline, feeling the rush of wind as you navigate through boundless horizons. Experience the exhilarating sensation of pushing limits and breaking barriers in this electrifying musical journey.

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Ep. 217: Corwyn Creating Generational Wealth With Single - Family Investment Properties

Optimizing The Total Cost Of Risk

Daggit was the kind of dog that didn’t need a pedigree to be special—he was a scrappy, brown terrier mix with no clear lineage, just a heart full of loyalty and a spirit that ran as free as the Texas wind. Found off old Pearsall Road, he jumped into the car like he had always belonged, instantly becoming the best friend of two young brothers who spent their days fishing, running through the front yard, and wandering wherever adventure called. Whether curled up in a lap, chasing them across the grass, or patiently watching as they cast lines into the pond, Daggit was always there—no leash, no rules, just unbreakable trust. No batteries needed, no fancy tricks—just a tail that wagged at the sight of them and a love that never faded, even as the years rolled on.

A Dog Named Daggit

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“Beyond the Edge” is an ethereal space ballad that explores the liminal zone between the known and the infinite. With imagery of drifting through the cosmos and surrendering to the vast unknown, it expresses the ache of longing, the beauty of release, and the haunting pull of the mysterious. Its repeated chorus becomes a mantra of letting go, while shimmering synths, ambient pads, and ghostly harmonies underscore the sensation of floating in a weightless realm beyond time. It's as much a spiritual metaphor as it is a cosmic journey—one of letting go of control and trusting the pull of something greater.

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Yo, I'm Foo.

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I am a hip-hop lyricist with a sharp wit and a knack for storytelling. Blending humor, pop culture references, and raw emotion, they craft tracks that hit hard and entertain. Whether it’s breaking down gaming culture, life’s struggles, or absurd moments with a comedic twist, their music keeps listeners nodding along and laughing at the same time. Always pushing creative boundaries, they turn everyday experiences into unforgettable bars.

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You don't need to be rich to invest in real estate. And you don't need to become a landlord either. In quick 5-20 minute bites, learn how to invest small amounts in passive real estate investments such as syndications, notes, and funds. We also cover how to buy properties actively if you do want to invest in real estate as a side hustle. With enough passive income, you reach financial independence — and your day job becomes optional.

Molecular imaging Specialist
Clinical trials reader
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