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Palestrante: Simone Santos (DF)
Moderador: Solomon Amaral (RJ)

#49 - Por que o ecocardiografista deve fazer o Dupplex scan de carótidas?

Palestrante: Dra. Ana Claudia Petisco
Moderador: Solomon Amaral (RJ)

#50 - Quais suas estratégias para quantificação das lesões estenóticas carotídeas.

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In this episode of AbbottTalks, Jennifer Jones-McMeans, PhD, Divisional VP of Global Clinical Affairs at Abbott and Brian DeRubertis, MD, Chief, Division of Vascular & Endovascular Surgery at Weill Cornell Medical Center tackle the complexities of treating peripheral arterial disease (PAD) below the knee, particularly chronic limb-threatening ischemia (CLTI), a severe form of PAD that drastically impacts patients' quality of life and longevity.

In the episode, the two discuss Abbott's Esprit BTK System, the first-and-only FDA-approved drug-eluting resorbable scaffold for infrapopliteal CLTI. Dr. Jones-McMeans explains how Esprit BTK works by releasing a drug that prevents artery re-narrowing, crucial for maintaining sustained blood flow and promoting wound healing. 

Later, they walk us through the pivotal LIFE-BTK trial, a significant milestone that demonstrated Esprit's efficacy and led to its FDA approval. They also highlight the importance of including diverse patient populations in clinical trials, particularly those disproportionately affected by PAD, such as African Americans, Latinos, Native Americans, and women. This inclusive approach not only ensures the treatment's effectiveness across varied demographics but also sets a precedent for future trials.

Thank you to Freudenberg Medical for sponsoring this episode of AbbottTalks. For more information on how Freudenberg Medical works with medical device companies, visit www.freudenbergmedical.com.

Thank you for listening to the AbbottTalks Podcast. Tune in and subscribe to DeviceTalks on all major podcast channels to never miss an episode.

Abbott’s Jones-McMeans and Dr DeRubertis on PAD below-the-knee, LIFE-BTK trial & Esprit BTK approval

In this episode of the Healthful Woman Podcast, Dr. Nathan Fox speaks with Dr. Tikva Jacobs, a vascular surgeon at the New York-Presbyterian/Weill Cornell Medical Center in NYC. They discuss everything varicose veins!

"Varicose Veins!" - with Dr. Tikva Jacobs

BUFFALO, NY- November 26, 2024 – This #editorial was #published by Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) in Volume 16, Issue 17, titled, “The silent protector: Nucleoporin93’s role in vascular health.”

Written by Julia Michalkiewicz, Tung D. Nguyen, and Monica Y. Lee from The University of Illinois at Chicago College of Medicine, this editorial highlights the critical role of a protein called Nucleoporin93 (Nup93) in maintaining blood vessel health as we age. The authors review new research suggesting that Nup93 could be a key target for treatments to prevent or reduce aging-related diseases, including heart disease and stroke.

Cardiovascular diseases remain the leading causes of death worldwide, with aging identified as a major risk factor. Vascular health declines as endothelial cells (EC)—the protective lining of blood vessels—lose their functionality with age. This deterioration leads to inflammation, arterial stiffening, and reduced blood flow, significantly increasing the risk of life-threatening diseases. The authors underscore the urgent need to uncover the molecular mechanisms driving these changes.

Nup93 plays an essential role within nuclear pore complexes (NPCs)—gateways that regulate molecular exchanges between the cell nucleus and cytoplasm. Age-related loss of Nup93 disrupts this delicate system, weakening endothelial cells function and accelerating vascular aging. Researchers identified Nup93 as a crucial protector of endothelial health, preventing harmful protein build-ups such as Yes-associated protein (Yap), a known driver of inflammation and cellular aging. 

Excitingly, scientists have discovered that restoring Nup93 levels in damaged endothelial cells can reverse some of these harmful effects. They also found that blocking Yap can prevent issues caused by low Nup93 levels. These findings highlight the potential for new medicines or therapies to protect blood vessels as people age. 

The authors propose that future treatments could involve delivering Nup93 directly to damaged blood vessels to restore their health and prevent cardiovascular diseases. They emphasize the importance of further research to uncover why Nup93 levels decrease with age and how restoring it might improve blood vessel function. 

“These latest discoveries provide a fresh and innovative perspective of EC biology, highlighting NPCs as major regulators of EC health that may underlie mechanisms of vascular aging and disease progression.”

In conclusion, the editorial encourages scientists to focus on understanding how endothelial cells stay strong and the role of NPCs in keeping blood vessels healthy. This research could lead to important breakthroughs in slowing down aging and improving people's quality of life.

DOI - https://doi.org/10.18632/aging.206097

Corresponding author - Monica Y. Lee - monicaYL@uic.edu

Video short - https://www.youtube.com/watch?v=as6opv9_FYM

Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts

About Aging-US

The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population.

The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.)

Please visit our website at https://www.Aging-US.com​​ and connect with us:

Facebook - https://www.facebook.com/AgingUS/
X - https://twitter.com/AgingJrnl
Instagram - https://www.instagram.com/agingjrnl/
YouTube - https://www.youtube.com/@AgingJournal
LinkedIn - https://www.linkedin.com/company/aging/
Pinterest - https://www.pinterest.com/AgingUS/
Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc

MEDIA@IMPACTJOURNALS.COM

Aging (Aging-US)

Nucleoporin93: A Silent Protector in Vascular Health

MTS is a condition that occurs when an artery crosses over the vein that drains the left leg, obstructing blood flow. It most commonly affects women between the ages of 20 and 40 who have been pregnant. If left untreated, it can lead to deep vein thrombosis (DVT)

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May-Thurner Syndrome Treatment

Erisipela é um processo infeccioso da pele, que pode atingir a gordura do tecido celular, causado por uma bactéria que se propaga pelos vasos linfáticos. Pode ocorrer em pessoas de qualquer idade, mas é mais comum nos diabéticos, obesos e nos portadores de deficiência da circulação das veias dos membros inferiores. Não é contagiosa.
Para falar sobre o tema, o âncora da Rádio Folha, Jota Batista conversou com o cirurgião vascular do Hospital Jayme da Fonte, Esdras Marques, no Canal Saúde.

28.01.25 - Canal Saúde - Erisipela: uma infecção que pode levar à morte. Como prevenir e tratar

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Flemona Crema es el remedio perfecto para combatir las enfermedades venosas y mejorar la circulación sanguínea. Disminuye la inflamación y el dolor debido a las varices y elimina las venas abultadas visibles en las piernas. Gracias a Flemona Cream, la mayoría de los pacientes con varices comenzaron a sentirse en orden y seguros de sí mismos, e incluso experimentaron mejoras en su calidad de vida.



Flemona Crema *Reduce Varices Rapidamente*

Cuando la sangre esta muy viscosa o espesa comienzan los problemas circulatorios. Comienzan las venas capilares a oscurecerse y mas tarde las venas se vuelven más prominentes. Comienzan los calambres, adormecimientos, moretones, dolor de cabeza, falta de concentración y más tarde esto es lo que se puede convertir en una embolia o en un ataque cardíaco. Si una persona se nota venitas en las piernas es porque tiene mala circulación y debe empezar a hacer algo cuanto antes para evitar males mayores.

Puede obtener este Programa en LA Farmacia Natural en Los Angeles, Van Nuys, Huntington Park, El Monte, Arleta, Pico Rivera, Long Beach y en Burbank o llamando a la Línea de la Salud, al 1-800-227-8428 si desean que se lo enviemos a su casa.


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Blue patches or swollen areas might be more than skin deep. Learn how to spot venous malformation in children, why early diagnosis matters, and what steps every parent should take for proper treatment.

Is It Just a Birthmark? Or a Hidden Venous Malformation in Your Child?

Vascular Surgeon New Haven County - Milford Vascular Institute provides varicose vein removal, spider vein treatment, & all vascular surgery

El programa de la nutricionista Neyda Carballo-Ricardo, transmitido 24 horas por Internet, inclusive en vivo desde Los Angeles, CA de lunes a viernes, 10 AM - 12 PM (Pacific Time) via Radio KWKW 1330 AM. Sintonize por Internet a cualquier hora para escuchar noticias, meditaciones, llamadas, y un premio cada viernes. Para mayor detalle, visite http://lafarmacianatural.com o llame al (800) 227-8428.

Aging-US is dedicated to advancing our understanding of the biological mechanisms that drive aging and the development of age-related diseases. Our mission is to serve as a platform for high-quality research that uncovers the cellular, molecular, and systemic processes underlying aging, and translates these insights into strategies to extend healthspan and delay the onset of chronic disease.

Read about the Aging (Aging-US) Scientific Integrity Process: https://aging-us.com/scientific-integrity

As principais notícias de Pernambuco, do Brasil e do mundo resumidas e comentadas pela Folha PE através de podcasts diários.
Fone: 81 3425-5872

The DeviceTalks Podcast Network delivers news, insights and commentary from MedTech industry leaders, primarily from the largest OEMs in healthcare. Our podcasts will inspire MedTech professionals to create better MedTech devices and companies.

Explore the DeviceTalks Podcast Network, home to more than 11 podcasts:

• DeviceTalks Weekly
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• Boston Scientific Talks
• DeviceTalks AI
• IntuitiveTalks
• MedtechWOMEN Talks
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• Neuro Innovation Talks: J&J MedTech Neuro
• Structural Heart Talks: Edwards Lifesciences
• Ortho Innovation Talks: Zimmer Biomet
• StrykerTalks

WATCH our video podcasts on www.youtube.com/@DeviceTalks

Connect with the hosts:
Tom Salemi, Editorial Director, DeviceTalks https://www.linkedin.com/in/tom-salemi-7118948/
Kayleen Brown, Managing Editor, DeviceTalks https://www.linkedin.com/in/kayleenbrown/

Learn more about DeviceTalks - Podcasts • Conferences • Webinars - www.devicetalks.com

New tracks tagged #Vascular