In this episode, Brion rejoins me to dive into a drug that has changed my life and may change yours.  I couldn’t just ride off into the sunset without telling you about the most amazing thing I've ever found!

Notes:

What is Rapamycin? Benefits and Side Effects: https://www.lifespan.io/news/what-is-rapamycin-a-summary-of-rapamycin/

New Scientist Rapamycin Article: https://www.newscientist.com/definition/rapamycin/

Rapamycin rejuvenates oral health in aging mice: https://pubmed.ncbi.nlm.nih.gov/32342860/

Doctors who prescribe Rapamycin: https://www.rapamycin.news/t/rapamycin-prescription-doctors-that-prescribe-it/69

Rapamycin Frequently Asked Questions: https://www.rapamycin.news/t/rapamycin-frequently-asked-questions-faq/59

Rapamycin protects aging muscle: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738401/

Dr. Mikhail Blagosklonny Twitter: https://twitter.com/Blagosklonny

Rapamycin: one drug, many effects: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972801/

Rapamycin (AY-22,989), a new antifungal antibiotic. IV. Mechanism of action:
https://pubmed.ncbi.nlm.nih.gov/381274/

History of Rapamycin:
https://www.bio-rad-antibodies.com/blog/history-of-rapamycin.html

Rapamycin and Longevity:
https://www.medicalnewstoday.com/articles/could-rapamycin-be-our-next-weapon-in-the-fight-for-longevity

Wound Healing Slowed in Mice: https://pubmed.ncbi.nlm.nih.gov/17524932/

About-face on the metabolic side effects of rapamycin: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413601/

Weighing the Anti-Aging Benefits of Rapamycin Against Possible Side Effects: https://www.naturemedclinic.com/weighing-the-anti-aging-benefits-of-rapamycin-against-possible-side-effects/

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Music by Jenny Jahlee from Live at KBOO

Quax Podcast

Ep. 101 Addendum: Rapamycin, the Anti Aging Drug That Will Change the World and Your Health

This is a small portion of some of my work.  To hear more please reach out to me at r.doggett@icloud.com or check out my website at www.rorydoggett.com

4. Home Depot TV Theme Song

3. Classical Orchestral (Regal & Minimal)

1. TRAILER (Fantasy & Adventure) - We Have Hope

Trailer - Blink And You'll Miss It

Testosterone Replacement Therapy is gaining popularity with many advocates and detractors. Lucas and Brion explore the evolutionary basis for testosterone and how that can inform your choice on whether to get on TRT

Notes:

Testosterone prescribing in the United States, 2002-2016: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396809/

Danish Study on Lowering T levels: https://academic.oup.com/jcem/article/92/12/4696/2597312#52560365

The He Hormone, 2000 New York Times: https://www.nytimes.com/2000/04/02/magazine/the-he-hormone.html

Testicle Shrinkage: https://www.thebodywellusa.com/will-taking-testosterone-make-testicles-shrink/

Testosterone Therapy and anabolic steroids: https://thinksteroids.com/steroid-profiles/testosterone/

TRT shuts down production of Pregnenolone and other upstream metabolites: https://www.sciencedirect.com/science/article/pii/0022473185902572?via%3Dihub

Supplementing Pregnenolone: https://www.testosteronewisdom.com/pregnenolone-what-you-need-to-know-about-this-precursor-hormone/

Forum thread on suppression: https://www.excelmale.com/forum/threads/anabolic-steroids-and-trt-decrease-shbg-dhea-pregnenolone-and-progesterone-in-men.3990/ 

T Trials showing Plaque Build Up: https://www.npr.org/sections/health-shots/2017/02/21/515456194/does-testosterone-improve-older-mens-health-it-depends

Evolutionary Psychology Wiki: https://en.wikipedia.org/wiki/Evolutionary_psychology

More Boy Children After War: https://www.popsci.com/scitech/article/2008-12/why-does-war-breed-more-boys/

Ghengis Khan’s 16 Million Children: https://www.thevintagenews.com/2018/06/09/genghis-khan/

NY Times Is There Anything Good about Men: https://tierneylab.blogs.nytimes.com/2007/08/20/is-there-anything-good-about-men-and-other-tricky-questions/
Low Free Testosterone Predicts Mortality from Cardiovascular Disease: https://academic.oup.com/jcem/article/97/1/179/2833341
Benefits and Risks of TRT: https://www.excelmale.com/trt-benefits-vs-risks/

The Testosterone Scam the Kills Healthy Men: https://www.healthscamsexposed.com/2014/03/the-testosterone-scam-that-kills-healthy-men/

Testosterone linked to shorter male lifespan: https://www.news.com.au/lifestyle/health/testosterone-linked-to-shorter-male-lifespan/news-story/539c29145e7b98692c176e182ee4f777

Testosterone Levels Drop after having kids: https://www.medicalnewstoday.com/articles/234266.php#1

Low Testosterone and Suicide: https://www.ncbi.nlm.nih.gov/pubmed/23893672

Lower Testosterone causing suicide?: https://www.1st-man.com/low-testosterone-male-suicide/

Silent Epidemic of Male Suicide: https://www.bcmj.org/articles/silent-epidemic-male-suicide

Music by Jenny Jahlee from Live at KBOO

Ep. 44 Testosterone Replacement Therapy: An Evolutionary Lens

In bygone times, there were traveling healers called "quack doctors" who would peddle potions and curealls from town to town.  Quacks were looked down upon for...well...poisoning lots people with mercury.  

But also for being empirical above any rational explanations, like humors and blood letting.  So when they weren't using mercury, these traveling quacks discovered bottom up health solutions through trial and error.  This podcast is about finding health solutions in the strangest places, even if they don't make sense

Ep. 101 Addendum: Rapamycin, the Anti Aging Drug That Will Change the World and Your Health

Quax

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