In this episode of The Deep Dive, we explore a large-scale study published in Dental and Medical Problems, revealing how systemic diseases show up in dental clinics. Based on data from over 82,000 adult patients in Mexico, the research shows that more than one in three had at least one chronic condition—most commonly gastrointestinal diseases, hypertension, or type 2 diabetes.

What does this mean for dentists, patients, and healthcare systems? We break down the key findings, gender and age-related trends, and what it all suggests about the evolving role of dental care in general health.

Tune in for insights on how oral health is deeply connected to whole-body wellness—and why a dental chair might just be the front line of preventive medicine.

This content was generated with the assistance of artificial intelligence (AI) tools: DeepDive (Notebook LM, Google).

Not Just a Toothache – What Do Systemic Diseases Reveal About Dental Patients?

In this episode, we dive into groundbreaking cancer research from the Medical University of Wrocław, where scientists are challenging traditional treatment methods with a surprisingly simple combo: electricity and calcium. Forget high-tech pharmaceuticals—this deep dive explores how short electric pulses can crack open cancer cells and let calcium do the damage. You’ll hear about the three-pronged attack on drug-resistant colon cancer cells, the mysterious “calcium paradox,” and how this method might one day boost the immune system while sparing healthy tissue. Join us as we decode the future of cancer therapy through the lens of nanosecond electroporation, mitochondrial collapse, and immune activation. This content was generated with the assistance of artificial intelligence (AI) tools: DeepDive (Notebook LM, Google).

Shock to cancer cells. Electric pulse and calcium can jointly destroy cancer

Feeding difficulties affect the vast majority of children with cerebral palsy—and yet one critical protective mechanism is often overlooked: the gag reflex. In this episode, we explore new research from Wroclaw Medical University highlighting the clinical importance of this reflex, its relationship to oral structure and muscle tone, and why early diagnosis and therapy matter.

This content was generated with the assistance of artificial intelligence (AI) tools: DeepDive (Notebook LM, Google).

The Gag Reflex – an underrated guardian

In this episode from we dive into the unique nutritional challenges faced by transgender individuals. The discussion highlights the absence of tailored dietary guidelines, the impact of hormone therapy on nutritional needs, and the heightened risks of disordered eating and food insecurity within the trans community. Emphasizing the importance of gender-affirming care, the episode calls for inclusive research and practices to better support trans health and well-being.

This content was generated with the assistance of artificial intelligence (AI) tools: DeepDive (Notebook LM, Google).

Transgender Nutrition Needs - Gaps and Directions

What if we could fight cancer like a sniper—targeting only the enemy, sparing the innocent? Researchers at Wroclaw Medical University are revolutionizing pediatric oncology with a novel approach that combines a natural marine compound—jasplakinolide—with electroporation, a technique that opens up cancer cells using precise electric pulses.

In this episode, we dive into: The science of precision therapy 
✔️ How electroporation allows ultra-targeted drug delivery 
✔️ Why jasplakinolide could be a breakthrough in fighting aggressive childhood cancers like rhabdomyosarcoma 
✔️ How healthy cells are spared while cancer cells collapse from within 
✔️ What this could mean for the future of chemotherapy-free treatments

This content was generated with the assistance of artificial intelligence (AI) tools: DeepDive (Notebook LM, Google).

Precision at the level of the cell - Electrical impulses versus striated muscle

Can Botox do more than smooth wrinkles? In this episode, we explore how botulinum toxin type A (BTX-A) is being used as an innovative therapy for bruxism — a condition affecting up to 20% of adults, causing jaw pain, tooth wear, and sleep disturbances. Based on a systematic review published in Dental and Medical Problems, we discuss the effectiveness, safety, and clinical potential of BTX-A in reducing symptoms of both sleep and awake bruxism. Tune in to find out whether Botox might become a new standard in dental treatment.

This content was generated with the assistance of artificial intelligence (AI) tools: DeepDive (Notebook LM, Google).

Botulinum Toxin for Bruxism - A Systematic Review

Ten materiał został wygenerowany przy wsparciu narzędzi sztucznej inteligencji (AI): DeepDive (Notebook LM, Google).

W tym odcinku podcastu zaglądamy do badań opublikowanych w czasopiśmie Polimery w Medycynie, wydawanym przez Uniwersytet Medyczny we Wrocławiu.

Tematem jest celeokoksyb – znany lek przeciwzapalny, który być może już niedługo znajdzie zastosowanie… w leczeniu chorób skóry. Ale zanim to się stanie, naukowcy muszą odpowiedzieć na jedno ważne pytanie: jakie podłoże dermatologiczne najlepiej uwalnia substancję czynną i zapewnia skuteczność leczenia?


Krem, żel czy oleożel? Jak wybrać najlepszy nośnik dla celekoksybu na skórę

This content was generated with the assistance of artificial intelligence (AI) tools: DeepDive (Notebook LM, Google).

How much science goes into a simple tube of cream? In this episode of Deep Dive, we unpack a study from Wroclaw Medical University, published in the journal Polymers in Medicine, that explores how different semi-solid bases—like gels, creams, and ointments—can radically affect the way a drug like celecoxib behaves on the skin.

From spreadability and texture to drug release rates, the researchers compared four pharmacy-compounding bases commonly used in Poland. The findings challenge assumptions and highlight how base formulation can make—or break—the effectiveness of a topical medication.
It's more than just mixing powder into a cream. It's pharmaceutical engineering at work.


Cream, gel, or oleogel? How to choose the best carrier for celecoxib for the skin

This content was generated with the assistance of artificial intelligence (AI) tools: DeepDive (Notebook LM, Google).

Why do chronic lymphocytic leukemia (CLL) cells refuse to die? In this episode, we explore the stubborn biology of CLL and a recent study that digs deep into how two drugs—venetoclax and cladribine—can work together to restore the self-destruct program in cancer cells.

We break down how this combination affects apoptosis-related gene expression, why the BCL2 protein is such a key player, and what happens when researchers zoom in on the genetic instructions, not just protein levels. Could this approach unlock more effective treatments for resistant CLL cases?

This content was generated with the assistance of artificial intelligence (AI) tools: DeepDive (Notebook LM, Google).

Combination therapies. Two drugs, one goal – killing cancer cells

Ten materiał został wygenerowany przy wsparciu narzędzi sztucznej inteligencji (AI): DeepDive (Notebook LM, Google).

Dlaczego komórki w przewlekłej białaczce limfocytowej (CLL) nie chcą umrzeć? W tym odcinku zagłębiamy się w uporczywą biologię CLL i omawiamy najnowsze badanie, które pokazuje, jak dwa leki — wenetoklaks i kladrybina — mogą wspólnie przywrócić mechanizm samozniszczenia w komórkach nowotworowych.

Przyglądamy się, jak to połączenie wpływa na ekspresję genów związanych z apoptozą, dlaczego białko BCL2 odgrywa tu kluczową rolę i co dzieje się, gdy badacze skupiają się na instrukcjach genetycznych, a nie tylko na poziomie białek. Czy takie podejście może przełożyć się na skuteczniejsze leczenie opornych przypadków CLL?

Terapie skojarzone. Dwa leki, jeden cel - śmierć komórek nowotworowych

Leading in medical research and education, Wrocław Medical University drives innovation in health sciences and clinical advancements. Based in Wrocław, Poland.

Shock to cancer cells. Electric pulse and calcium can jointly destroy cancer

Wroclaw Medical University

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