In this episode, our guests reflect on 25 years of NICE, how the organisation has developed, the impact its had and how it will change to adapt to the challenges of the next 25 years.

Guests: NICE CEO Dr Sam Roberts, Chief Medical Officer for England Professor Sir Chris Whitty, MHRA CEO Dame June Raine, Director of Value and Access at Association of British HealthTech Industries Luella Trickett, and Director of the Bennett Institute for Applied Data Science Ben Goldacre.

Read more about 25 years of helping to get the best care to people fast: https://indepth.nice.org.uk/NICE-at-25/index.html

25 years of NICE and focusing on what matters most to deliver for the future

DOI: 10.13056/acamh.28495
https://doi.org/10.13056/acamh.28495

In this Papers Podcast, Dr. John Weisz discusses his JCPP paper ‘Research Review: The internalizing paradox – youth anxiety and depression symptoms, psychotherapy outcomes, and implications for research and practice’ (https://doi.org/10.1111/jcpp.13820).

There is an overview of the paper, methodology, key findings, and implications for practice.

Discussion points include:

- An explanation of what the internalizing paradox is.
- The five different possible explanations for the internalizing paradox.
- The differential comorbidities between anxiety disorders and depressive disorders.
- Insight into ‘variegated nature of polythetic conditions’.
- A definition of differential progress in the search for mechanisms of change.
- How differential complexity of evidence-based psychotherapy protocols relate to the internalizing paradox.
- The clinician's challenge.
- How the different perspectives suggest different treatment strategies and insight into these strategies.
- The limitations of current research and the possible avenues for future work.
- Implications for clinicians and how this research impacts interventions.
- Messages for parents and carers and the importance of parents/carers partnering with clinicians with regards to interventions.

In this series, we speak to authors of papers published in one of ACAMH’s three journals. These are The Journal of Child Psychology and Psychiatry (JCPP); The Child and Adolescent Mental Health (CAMH) journal; and JCPP Advances.

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The Internalizing Paradox - Youth Anxiety and Depression Symptoms

DOI: 10.13056/acamh.27603
https://doi.org/10.13056/acamh.27603

In this In Conversation podcast, Dr. Seonaid Anderson is joined by Professor Chris Hollis, who is leading a research team working on a research project about ADHD medication and Tics. The focus of this podcast is on this research project, called The SATURN Trial.

The full name of the trial is the ‘Stimulant Medication for ADHD and Tics – Understanding Response versus Non-stimulants (SATURN): a randomised trial of the clinical and cost-effectiveness of methylphenidate versus Guanfacine for ADHD in children and young people with a co-existing tic disorder’.

Discussion points include:

- Definition of Tics and ADHD.
- Potential challenges of differentiating between tics from a Tic Disorder, such as Tourette Syndrome, from other movements from conditions such as chorea dystonia myoclonus.
- Differentiating between stimming movements and tics.
- The reason behind The SATURN Trial and how it is funded.
- The effectiveness of non-stimulant medication in treating the symptoms of ADHD.
- Co-morbidity and Tic Disorders.
- Impact of the ongoing shortage of ADHD medication on patients.
- Why people should be encouraged to get involved in this research and the clinical implications from this research.

This episode is part of The Association for Child and Adolescent Mental Health’s series on Tourette Syndrome and Tic Disorders. The series explores the evidence-based research on Tourette Syndrome, and other Tic Disorders, as well as the education, treatments, and research in this area.

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ADHD and Tic Disorders: Discussing the SATURN Trial

DOI: 10.13056/acamh.27597
https://doi.org/10.13056/acamh.27597

In this Papers Podcast, Maria Palma and Associate Professor Alice Goisis discuss their co-authored JCPP paper ‘Medically assisted reproduction and mental health in adolescence: evidence from the UK Millennium Cohort Study’ (https://doi.org/10.1111/jcpp.13877).

There is an overview of the paper, methodology, key findings, and implications for practice.

Discussion points include:

- What the UK Millennium Cohort Study is.
- The differences in parental reports on adolescent mental health between MAR (medically assisted reproduction) adolescents and naturally conceived adolescents.
- The differences between adolescent self-reports and parental reports on adolescent mental health.
- The association between MAR conception and mental health outcomes in adolescents.
- Implications for clinical practice and researchers.

In this series, we speak to authors of papers published in one of ACAMH’s three journals. These are The Journal of Child Psychology and Psychiatry (JCPP); The Child and Adolescent Mental Health (CAMH) journal; and JCPP Advances.

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Medically Assisted Reproduction and Mental Health in Adolescence

We're joined by Mark Chapman, director of NICE's HealthTech programme and Verena Stocker, director of Innovation, Research, Life Sciences and Strategy at NHS England to discuss the benefits and opportunities the proposed pathway will offer.

Take part in the consultation: https://www.engage.england.nhs.uk/specialised-commissioning/building-an-integrated-rules-based-medtech-pathway/

Learn more about the NICE and NHS England MedTech Pathway consultation

DOI: 10.13056/acamh.28954
https://doi.org/10.13056/acamh.28954

In this Papers Podcast, Dr. Matti Cervin discusses his JCPP paper ‘Efficacy and acceptability of cognitive-behavioral therapy and serotonin reuptake inhibitors for pediatric obsessive-compulsive disorder: a network meta-analysis’ (https://doi.org/10.1111/jcpp.13934). Matti is the lead author of the paper.

There is an overview of the paper, methodology, key findings, and implications for practice.

Discussion points include:

- The importance of examining efficacy and acceptability of cognitive-behavioural therapy and serotonin reuptake inhibitors in the context of the pediatric population.
- The two domains of treatments that have an evidence base for paediatric obsessive-compulsive disorder (OCD) – cognitive-behavioural therapy and medication.
- The difference between different forms of cognitive-behavioural therapy (CBT) delivery – traditional in-person, remote CBT, and internet-delivered CBT.
- Difference between in-person CBT and internet-delivered CBT.
- Implications for policymakers and child and adolescent mental health professionals.

In this series, we speak to authors of papers published in one of ACAMH’s three journals. These are The Journal of Child Psychology and Psychiatry (JCPP); The Child and Adolescent Mental Health (CAMH) journal; and JCPP Advances.

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Which Treatments Work for Pediatric OCD?

DOI: 10.13056/acamh.27660
https://doi.org/10.13056/acamh.27660

In this In Conversation podcast, Dr. Seonaid Anderson is joined by Dr. Charlotte Hall, Dr. Tammy Hedderly, Joe Kilgariff, and Lisa Rudge for a round table discussion on Tics and Tic Disorders, such as Tourette Syndrome.

Discussion points include:

- The prevalence of Tics and Tic Disorders and to what extent are Tics and Tic Disorders still a misunderstood condition.
- Diagnosis as a gateway to getting support and the difficulty of receiving a diagnosis.
- The importance of increasing a general understanding of what Tics are.
- The impact of labelling and the language used and the surrounding discourse.
- The two main strands of treatment – the medication strand and the Behavioural Therapy strand – and the challenges of accessing treatment.
- Importance of collaboration between patient community, the associations and health professionals and how to get more patients involved in research.
- Overview of some current research projects, including the INTEND project and the ORBIT-UK study.
- The need for NICE guidelines on Tic Disorders to improve diagnosis, treatment, and management, and the impact of the lack of NICE guidelines on equity of services.

This episode is part of The Association for Child and Adolescent Mental Health’s series on Tourette Syndrome and Tic Disorders. The series explores the evidence-based research on Tourette Syndrome, and other Tic Disorders, as well as the education, treatments, and research in this area.

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Understanding Tic Disorders: A Round Table on Diagnosis, Treatment, and Research

DOI: 10.13056/acamh.30077
https://doi.org/10.13056/acamh.30077

In this In Conversation podcast, Dr. Seonaid Anderson is joined by Dr. Maddie Groom, Dr. Holan Liang, Dr. Camilla Babbage, Emma McNally, and Dr. Andrew Curran for a round table discussion on Tics and Tic Disorders, such as Tourette Syndrome.

Discussion points include:

- The build-up of momentum and awareness raising around Tics and Tic Disorders.
- The lack of clear clinical pathways in many parts of the UK for how referrals for Tics and Tourette’s are dealt with.
- The importance of patient and family voices in service development and the challenges people with Tourette Syndrome are facing in accessing services.
- What can be done in terms of getting the attention of Commissioners or changing the structure.
- How NICE guidelines for Tourette Syndrome could change the field.
- How best to support healthcare professionals in their work regarding Tics and Tourette Syndrome.

This episode is part of The Association for Child and Adolescent Mental Health’s series on Tourette Syndrome and Tic Disorders. The series explores the evidence-based research on Tourette Syndrome, and other Tic Disorders, as well as the education, treatments, and research in this area.

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Ready for Change? The Changing Picture of Tourette Syndrome in the UK

DOI: 10.13056/acamh.28984
https://doi.org/10.13056/acamh.28984

In this Papers Podcast, Dr. Tom Cawthorne and Professor Roz Shafran discuss their JCPP Advances paper ‘Do single-case experimental designs lead to randomised controlled trials of cognitive behavioural therapy interventions for adolescent anxiety and related disorders recommended in the National Institute of Clinical Excellence guidelines? A systematic review’ (https://doi.org/10.1002/jcv2.12181).

There is an overview of the paper, methodology, key findings, and implications for practice.

Discussion points include:

- How the single-case experimental design (SCED) approach works and insight into the construct of the hierarchy of evidence.
- How the review was conducted and why they focused on adolescent anxiety.
- Adolescents as an under-researched population and the practical challenges around the SCED design.
- The evidence that the SCED design can be a helpful approach and can provide high-quality research evidence.
- The implications for researchers and research policymakers as well as CAMH professionals.
- Could using SCEDs more effectively lead to future NICE guidelines better representing the adolescent population?
- The recommendations that emerge from the paper.

In this series, we speak to authors of papers published in one of ACAMH’s three journals. These are The Journal of Child Psychology and Psychiatry (JCPP); The Child and Adolescent Mental Health (CAMH) journal; and JCPP Advances.

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The Hierarchy of Evidence: Single-Case Experimental Designs and CBT Interventions for Anxiety

We are committed to multi-disciplinary research and practice within child and adolescent mental health. We do this through publication of new research findings and dissemination of innovative practices. We are a membership organisation that brings together professionals from a range of disciplines to advance standards and support the professional development of all those working to support the mental health of children and young people.

Medically Assisted Reproduction and Mental Health in Adolescence

ACAMH

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